FOXL2 Antibody (262C1a): sc-81275
- FOXL2 Antibody (262C1a) is a mouse monoclonal IgG1 κ FOXL2 antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of FOXL2 of human origin
- recommended for detection of FOXL2 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FOXL2 Antibody (262C1a). This work is in progress.
FOXL2 Antibody (262C1a) is a mouse monoclonal IgG1 kappa light chain antibody that detects FOXL2 protein of human origin by western blotting (WB) and immunoprecipitation (IP). FOXL2 (262C1a) antibody is available as a non-conjugated monoclonal isotype antibody. FOXL2 protein, consisting of 376 amino acids, is encoded by FOXL2 gene and is primarily located in the nucleus, where FOXL2 functions as a transcriptional regulator. This regulatory role is crucial as FOXL2 is involved in the development and maintenance of ovarian function, and dysregulation can lead to significant reproductive disorders. Notably, mutations in FOXL2 are linked to blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES), an autosomal dominant condition characterized by eyelid dysplasia and associated with female infertility in type I BPES. FOXL2 structure includes a poly-Ala domain, which is a mutational hotspot; approximately 30% of mutations in the open reading frame lead to expansions in this domain, predominantly resulting in type II BPES. Additionally, defects in FOXL2 are implicated in premature ovarian failure type 3 (POF3), a condition marked by the cessation of ovarian function before the age of 40, highlighting FOXL2′s importance in reproductive health.
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FOXL2 Antibody (262C1a) References:
- Spectrum of FOXL2 gene mutations in blepharophimosis-ptosis-epicanthus inversus (BPES) families demonstrates a genotype--phenotype correlation. | De Baere, E., et al. 2001. Hum Mol Genet. 10: 1591-600. PMID: 11468277
- The human FOXL2 mutation database. | Beysen, D., et al. 2004. Hum Mutat. 24: 189-93. PMID: 15300845
- A new heterozygous mutation of the FOXL2 gene is associated with a large ovarian cyst and ovarian dysfunction in an adolescent girl with blepharophimosis/ptosis/epicanthus inversus syndrome. | Raile, K., et al. 2005. Eur J Endocrinol. 153: 353-8. PMID: 16131596
- Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. | Lee, K., et al. 2005. Biochem Biophys Res Commun. 336: 876-81. PMID: 16153597
- Blepharophimosis and bilateral Duane syndrome associated with a FOXL2 mutation. | Vincent, AL., et al. 2005. Clin Genet. 68: 520-3. PMID: 16283882
- Three novel FOXL2 gene mutations in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome. | Or, SF., et al. 2006. Chin Med J (Engl). 119: 49-52. PMID: 16454982
- Molecular cloning and analysis of gonadal expression of Foxl2 in the medaka, Oryzias latipes. | Nakamoto, M., et al. 2006. Biochem Biophys Res Commun. 344: 353-61. PMID: 16630569
- Foxl2 function in ovarian development. | Uhlenhaut, NH. and Treier, M. 2006. Mol Genet Metab. 88: 225-34. PMID: 16647286
- FOXL2 activates P450 aromatase gene transcription: towards a better characterization of the early steps of mammalian ovarian development. | Pannetier, M., et al. 2006. J Mol Endocrinol. 36: 399-413. PMID: 16720712
- FOXL2 impairment in human disease. | Verdin, H. and De Baere, E. 2012. Horm Res Paediatr. 77: 2-11. PMID: 22248822
- FOXL2: a central transcription factor of the ovary. | Georges, A., et al. 2014. J Mol Endocrinol. 52: R17-33. PMID: 24049064
- FOXL2 interaction with different binding partners regulates the dynamics of ovarian development. | Migale, R., et al. 2024. Sci Adv. 10: eadl0788. PMID: 38517962
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FOXL2 Antibody (262C1a) | sc-81275 | 100 µg/ml | $333.00 |