FOXI1 Activators
FOXI1 activators are a class of small molecules or compounds that play a crucial role in the modulation of gene expression by targeting the FOXI1 transcription factor. FOXI1, short for Forkhead Box I1, is a member of the Forkhead box (FOX) family of transcription factors, which are known for their involvement in the regulation of various cellular processes, including development, differentiation, and homeostasis. FOXI1 itself is primarily recognized for its role in the development and maintenance of various tissues and organs, such as the inner ear, kidney, and the urogenital system.
FOXI1 activators, as the name suggests, are compounds that enhance the activity of FOXI1 by binding to it or its associated regulatory elements. These activators can function at the molecular level by promoting the transcription of genes under the control of FOXI1, thereby influencing the development and function of tissues and organs where FOXI1 is expressed. Understanding the mechanisms and molecules that can activate FOXI1 is of great significance, as it can shed light on the intricate processes of organogenesis and tissue maintenance. Research into FOXI1 activators provides valuable insights into the molecular pathways and regulatory networks involved in these essential biological processes, and this knowledge can have implications in various fields, including developmental biology and tissue engineering.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is a derivative of vitamin A and acts as a transcriptional activator for FOXI1. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine can activate FOXI1 by binding to its cell surface receptors, such as beta-adrenergic receptors. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin stimulates the production of cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA). PKA, in turn, can phosphorylate transcription factors that enhance FOXI1 promoter activity, thus increasing FOXI1 gene expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
LiCl can activate the Wnt signaling pathway, which is known to play a role in FOXI1 expression. Activation of this pathway by LiCl can lead to the upregulation of FOXI1 gene expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid is a histone deacetylase (HDAC) inhibitor. By inhibiting HDACs, valproic acid can increase histone acetylation, leading to a more permissive chromatin structure around the FOXI1 promoter region and enhanced FOXI1 transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is an HDAC inhibitor similar to valproic acid. By inhibiting HDACs, TSA promotes histone acetylation, leading to an open chromatin structure around the FOXI1 promoter and increased FOXI1 transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is another HDAC inhibitor that can alter chromatin structure by increasing histone acetylation. This can result in the activation of FOXI1 by making its promoter more accessible to transcription factors. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC can activate various signaling pathways, including those that may stimulate FOXI1 transcription by phosphorylating transcription factors or other regulators. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is a selective inhibitor of the transforming growth factor-beta (TGF-β) signaling pathway. FOXI1 expression can be negatively regulated by TGF-β signaling, so inhibiting this pathway with SB431542 can lead to increased FOXI1 expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid that can activate glucocorticoid receptors. These receptors can translocate to the nucleus and influence gene transcription, potentially including FOXI1. | ||||||