Fnk Activators
The term Fnk activators refers to a class of chemicals or compounds that are known to stimulate the activation or increase the activity of the Polo-like Kinase 3 (PLK3) enzyme within biological systems. PLK3, also known as Prk or Fnk, is a serine/threonine kinase belonging to the PLK family of kinases. These kinases play pivotal roles in regulating various cellular processes, including cell cycle progression, DNA damage response, and mitotic events.
PLK3 activators can encompass a diverse range of molecules that affect PLK3 activity through different mechanisms. Some of these activators may induce phosphorylation events, leading to PLK3 activation and subsequent downstream signaling cascades. Others might modulate the expression or stability of PLK3 protein itself. Additionally, certain activators could promote the assembly of PLK3 into active complexes with other proteins, facilitating its functions in various cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine enhances PLK3 activation indirectly by affecting DNA damage checkpoints. It inhibits ATM and ATR kinases, disrupting DNA damage response pathways and potentially leading to PLK3 activation. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide (H2O2) acts as a reactive oxygen species (ROS) that can trigger PLK3 activation in response to oxidative stress and oxidative DNA damage. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin activates PLK3 due to DNA damage. It inhibits topoisomerase I, leading to DNA strand breaks and activation of DNA damage response pathways, including PLK3 activation. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubules, indirectly influencing PLK3 activity by affecting cell cycle progression and cell cycle checkpoints. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that may indirectly influence PLK3 activation through epigenetic regulation, altering histone acetylation patterns and gene expression. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid inhibits phosphatases, including PP2A, leading to increased PLK3 phosphorylation and activation. It sustains the phosphorylation state of PLK3, contributing to its activation. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin activates PLK3 as part of the cellular response to genomic instability caused by DNA damage. It forms covalent bonds with DNA, triggering DNA damage response pathways, including PLK3 activation. | ||||||