Fndc3c1 Activators
Fndc3c1 activators are a classification of chemical agents that play a role in modulating cellular functions by targeting the protein fibronectin type III domain containing 3C1. The interaction with this protein can lead to a cascade of intracellular events, primarily influencing cell adhesion, cell-matrix interactions, and dynamic cellular infrastructure modifications. These activators encompass a variety of compounds with diverse chemical structures and modes of action, all converging on the common endpoint of enhancing the activity of fibronectin type III domain containing 3C1. Some activators function by directly stimulating specific enzymes or inhibiting others to increase the levels of secondary messengers within the cell, such as cAMP, which in turn activates protein kinases that can phosphorylate target proteins, including those associated with the fibronectin type III domain.
The fibronectin type III domain is a critical structural motif found in a vast array of proteins, including growth factors, receptors, and extracellular matrix components, which underscores the importance of its regulatory mechanisms. Fndc3c1 activators can affect signaling pathways like the MAPK cascade, PI3K/AKT network, and others that are central to the organization and function of the cytoskeleton. For instance, some compounds within this class can modulate the activity of enzymes like protein kinase A or protein kinase C, which have roles in cell mobility and morphology. Others might target tyrosine kinases or specific phosphatases, thereby altering the phosphorylation state of proteins that interact with the fibronectin type III domain, leading to changes in cell adhesion properties. The diversity of these activators is also reflected in their varied chemical structures, which range from small organic molecules to larger, more complex polyphenolic compounds.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, which increases intracellular cAMP levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate target proteins involved in cell adhesion and motility, potentially enhancing the activity of fibronectin type III domain containing 3C1 by promoting its interaction with integrins and other extracellular matrix proteins. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit the activity of matrix metalloproteinases (MMPs). By inhibiting MMPs, the turnover of the extracellular matrix is reduced, potentially stabilizing the matrix structure and enhancing the activity of fibronectin type III domain containing 3C1 as it is involved in matrix assembly and cell-matrix interactions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in various cell signaling pathways. Activation of PKC can lead to the phosphorylation of proteins that interact with fibronectin type III domain containing 3C1, thereby potentially enhancing its function related to cell adhesion and migration. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 stabilizes β-catenin, which can then enter the nucleus and activate transcription of genes involved in cell adhesion, potentially enhancing the activity of fibronectin type III domain containing 3C1 in this context. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), leading to an increase in cAMP levels, similar to Forskolin. This elevation can enhance PKA activity, possibly contributing to an increased functional activity of fibronectin type III domain containing 3C1 by affecting cell adhesion dynamics. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK). By inhibiting ROCK, the actin cytoskeleton's organization is affected, which can lead to changes in cell shape and movement, potentially enhancing the functional activity of fibronectin type III domain containing 3C1 in cellular adhesion processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK. Inhibition of p38 MAPK can lead to alterations in the cellular response to stress and inflammation, potentially enhancing the activity of fibronectin type III domain containing 3C1 through changes in the extracellular matrix composition and cell adhesion properties. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. It can enhance fibronectin type III domain containing 3C1 activity by preventing phosphorylation of proteins that may negatively regulate cell adhesion and migration, where fibronectin type III domain containing 3C1 is functionally active. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). Inhibiting JNK can shift cell signaling towards pathways that support cell survival and adhesion, potentially enhancing the activity of fibronectin type III domain containing 3C1 in these pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By blocking PI3K, this compound can affect the AKT signaling pathway, which is involved in cell survival and adhesion. This might enhance the functional activity of fibronectin type III domain containing 3C1 by influencing the cellular processes it is involved in. | ||||||