FLRT2 Inhibitors
FLRT2 inhibitors belong to a class of small molecule compounds specifically designed to target and modulate the activity of the fibronectin leucine-rich transmembrane protein 2 (FLRT2). FLRT2 is a member of the FLRT family of transmembrane proteins, which are involved in various cellular processes, including cell adhesion, migration, and neurite outgrowth. These inhibitors are engineered to selectively bind to FLRT2, altering its function and interfering with downstream signaling pathways. At the molecular level, FLRT2 inhibitors are characterized by their unique chemical structures, which possess key features essential for effective interaction with the target protein. The active site of FLRT2, where these inhibitors bind, is a pocket-like region with specific amino acid residues that provide the necessary interactions for binding. The inhibitors' chemical moieties are tailored to complement the shape and properties of this pocket, allowing for high-affinity binding and specificity towards FLRT2.
Inhibition of FLRT2 through these compounds disrupts its normal functions in cell adhesion and neurite outgrowth. FLRT2 plays a critical role in guiding axonal growth and neural circuit formation during embryonic development and in the adult nervous system. Research into FLRT2 inhibitors is still in its early stages, and ongoing studies aim to uncover the precise mechanisms of action and downstream effects of these compounds. As researchers delve deeper into the molecular interactions between the inhibitors and FLRT2, a more comprehensive understanding of their potential applications in cellular and developmental biology is expected to emerge.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A phosphoinositide 3-kinase (PI3K) inhibitor that blocks PI3K/Akt signaling. This action can reduce cell proliferation and migration, indirectly affecting FLRT2's role in cell adhesion and motility. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An MEK inhibitor that obstructs the MAPK/ERK pathway, potentially diminishing FLRT2's contribution to cellular processes like neurite outgrowth through indirect modulation of pathway-specific transcription factors. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor that can alter cellular responses to stress and inflammation, indirectly influencing FLRT2's involvement in these processes by modulating the pathway's downstream effectors. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor that impedes actin cytoskeleton organization and cell motility. Given FLRT2's role in cell adhesion, inhibiting ROCK can indirectly reduce FLRT2-mediated cellular interactions. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor that can affect cell proliferation, apoptosis, and differentiation, indirectly modulating FLRT2's function in these processes by altering JNK pathway activity. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
An AMPK inhibitor, also known to inhibit BMP signaling. By affecting these pathways, it could indirectly influence FLRT2's role in developmental processes and cellular differentiation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
An inhibitor of MEK1/2, preventing the activation of MAPK/ERK pathway. This modulation can indirectly affect FLRT2's role in signal transduction related to cell adhesion and migration. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A potent PI3K inhibitor, affecting various cellular processes including growth and survival, potentially modulating FLRT2 activity indirectly through changes in cell signaling dynamics. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
A Wnt pathway inhibitor targeting β-catenin mediated transcription. By influencing Wnt signaling, it can indirectly modulate FLRT2's impact on cellular communication and tissue patterning. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
A PKC inhibitor, affecting the phosphorylation status of various substrates involved in cell migration and adhesion, potentially altering FLRT2's function in these processes indirectly. | ||||||