FILIP1L Inhibitors
Chemical inhibitors of FILIP1L can impact various cellular pathways and processes by targeting specific enzymes and kinases that play a role in the regulation of this protein's function. For instance, Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6, can lead to reduced cell proliferation by indirectly inhibiting FILIP1L functions associated with cell cycle progression. Similarly, Rapamycin, which inhibits the mTOR pathway, can suppress the pathways involving FILIP1L in cell growth and survival. Trichostatin A, an inhibitor of histone deacetylase, can alter the chromatin structure, potentially affecting the pathways necessary for FILIP1L's role in gene expression regulation.
Furthermore, LY294002 and Wortmannin are both PI3K inhibitors that can reduce Akt signaling, thereby inhibiting FILIP1L-associated functions in cell survival and growth. U0126 and PD98059, both inhibitors of MEK1/2, impact the ERK pathway, which is involved in processes that FILIP1L influences, such as cell differentiation and proliferation. SB203580, which inhibits p38 MAP kinase, can lead to the functional inhibition of FILIP1L's roles in response to cellular stress. In addition to these, Y-27632, a ROCK inhibitor, can lead to cytoskeletal changes that inhibit FILIP1L's functions related to cell movement and structure. SP600125, an inhibitor of JNK, can inhibit FILIP1L's role in apoptosis signaling pathways. Lastly, imatinib and sunitinib target tyrosine kinases and receptor tyrosine kinases, respectively, which are involved in signaling pathways that can affect FILIP1L's role in processes such as actin filament dynamics and cell growth.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib is a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. FILIP1L is implicated in cell cycle regulation and palbociclib's inhibition of CDK4/6 can lead to reduced cell proliferation, which may indirectly inhibit FILIP1L's function in promoting cell cycle progression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. FILIP1L has been linked to pathways involving cell growth and survival, which are regulated by mTOR. Inhibition of mTOR may therefore suppress the pathways that FILIP1L is involved in, indirectly inhibiting its function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylase (HDAC). FILIP1L has been associated with gene expression regulation; therefore, HDAC inhibition can alter the chromatin structure and potentially downregulate pathways necessary for FILIP1L's role in gene expression control. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. Since FILIP1L has been reported to be involved in the PI3K/Akt signaling pathway, inhibition of PI3K could reduce Akt signaling, thereby indirectly inhibiting FILIP1L associated functions in cell survival and growth. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream regulators of the ERK pathway. FILIP1L is involved in cellular processes regulated by the ERK pathway, so inhibition of MEK1/2 might lead to a decrease in ERK-mediated functions, potentially inhibiting FILIP1L's role in these processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, similar to U0126, and would functionally inhibit FILIP1L by the same mechanism, i.e., through the inhibition of the ERK pathway, which is involved in processes that FILIP1L influences. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor. FILIP1L's function in stress response could be influenced by p38 MAPK pathway, so inhibition of p38 MAPK may lead to functional inhibition of FILIP1L's roles in response to cellular stress. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor. Given FILIP1L's role in cell shape and motility, inhibition of ROCK may lead to cytoskeletal changes that could inhibit FILIP1L's functions related to cell movement and structure. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK. Since FILIP1L is implicated in apoptosis and JNK is part of the apoptosis signaling pathway, inhibition of JNK could lead to functional inhibition of FILIP1L's role in apoptosis. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor, like LY294002, and would inhibit FILIP1L by preventing activation of the PI3K/Akt pathway, which is essential for FILIP1L's role in cell proliferation and survival. | ||||||