FILIA Activators
FILIA Activators are a class of compounds that enhance the functional activity of the protein FILIA indirectly by influencing various pathways and cellular processes that FILIA is involved in. FILIA is known for its role in chromatin remodeling and DNA damage response during meiosis. Compounds like Resveratrol and Epigallocatechin gallate can enhance pathways that are pivotal for DNA repair and chromatin structure modifications, thus indirectly facilitating FILIA's function. Resveratrol, through the activation of SIRT1, can lead to a favorable chromatin state for FILIA's action, whereas Epigallocatechin gallate promotes base excision repair, creating a conducive environment for FILIA's role in genomic stability.
Additionally, compounds such as Curcumin and Sulforaphane activate the NRF2 pathway, which oversees the expression of defense proteins against oxidative DNA damage. This activation reduces oxidative stress levels, thereby supporting the genomic integrity maintenance role of FILIA. Similarly, Quercetin and Genistein are involved in the enhancement of DNA repair mechanisms. Quercetin facilitates the repair of DNA double-strand breaks, which can indirectly be advantageous for FILIA's function during meiotic cell division. Genistein's stimulation of DNA damage response pathways offers an environment where FILIA's activity in DNA repair is vital. Zinc's role as a vital cofactor in DNA repair enzyme function indirectly complements FILIA's role in genomic maintenance. N-Acetylcysteine, through its capacity to boost cellular antioxidant capabilities, indirectly ensures a cellular environment that is favorable for FILIA's role in meiosis. Omega-3 fatty acids, known to modulate oxidative stress, indirectly support FILIA by maintaining genomic stability. Lycopene contributes to the enhancement of the DNA damage response, while Melatonin, by improving the DNA damage response efficiency, may bolster FILIA's function in sustaining genomic integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to activate the SIRT1 pathway, which plays a role in chromatin remodeling and DNA repair. Through SIRT1 activation, it can enhance the chromatin structure modifications necessary for FILIA to facilitate accurate homologous recombination during meiosis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This catechin, predominant in green tea, can activate DNA repair enzymes that are involved in the base excision repair pathway. By enhancing the activity of these enzymes, it can create an environment that favors FILIA's role in maintaining genomic stability during cell division. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates the NRF2 pathway, which regulates the expression of antioxidant proteins that protect against oxidative damage. By promoting an antioxidative environment, curcumin supports the genomic integrity that FILIA is known to maintain during meiosis. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is an inducer of phase II detoxification enzymes through the activation of the NRF2 pathway. It can indirectly support the function of FILIA by reducing oxidative stress and maintaining genomic stability, a process vital to FILIA's role in gametogenesis. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is known to enhance the repair of DNA double-strand breaks by non-homologous end joining (NHEJ). While NHEJ is typically error-prone, the presence of FILIA could be indirectly supported by quercetin as it enhances DNA repair mechanisms where FILIA might be involved. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone from soy, can activate DNA damage response pathways. By enhancing the activity of these pathways, genistein can indirectly enhance the functional activity of FILIA, which is involved in the DNA damage response during meiosis. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid has been shown to promote DNA repair mechanisms. By doing so, it can create a cellular context that supports the role of FILIA in ensuring genomic integrity during the DNA damage response. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a cofactor for many DNA repair enzymes. By ensuring the proper function of these enzymes, zinc indirectly supports the activities of proteins like FILIA that are involved in genomic maintenance and stability. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
As a precursor to glutathione, N-Acetylcysteine can enhance cellular antioxidative capabilities, indirectly supporting FILIA's function in protecting genomic integrity during meiosis by maintaining a reduced intracellular environment. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $143.00 $571.00 $6125.00 | 4 | |
Lycopene, a carotenoid found in tomatoes, can reduce oxidative stress and has been implicated in the enhancement of the DNA damage response. This can indirectly support the function of FILIA in genomic maintenance during meiosis. | ||||||