Date published: 2025-9-10

021-6093-6350

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FGF-8F激活剂

The chemical class known as FGF-8F activators encompasses a variety of compounds that can influence the modulation of the FGF-8F protein's activity through their interaction with several cellular signaling pathways. These activators are primarily characterized by their ability to interfere with the intracellular signaling cascades that FGF-8F is known to be involved in, such as the MAPK, PI3K/AKT, and PLCγ pathways. The actions of these chemicals result in cellular responses that can lead to the activation of FGF-8F signaling, albeit in an indirect fashion, by triggering a complex network of regulatory mechanisms within the cell.

The chemical activators in this class typically function by inhibiting specific enzymes or kinases that are crucial components of the signaling pathways related to FGF-8F activity. This inhibition can result in the alteration of the cellular signaling environment, which can, in turn, trigger compensatory responses that activate FGF-8F signaling. These responses may include the upregulation of other signaling molecules, alteration of receptor sensitivities, or changes in the expression levels of various downstream targets. By affecting these pathways, the activators can influence the cellular processes that are governed by FGF-8F, such as cell proliferation, differentiation, and survival. The diversity of these compounds allows for the modulation of FGF-8F signaling in multiple contexts, reflecting the broad biological roles that FGF-8F plays in cellular function.

関連項目

产品名称CAS #产品编号数量价格应用排名

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

U0126 是 MAPK 通路中一种激酶 MEK 的选择性抑制剂;通过抑制 MEK,U0126 可导致激活 FGF8 信号的代偿机制。

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

一种 PI3K 抑制剂,可破坏下游 AKT 信号传导,从而通过细胞信号反馈回路影响 FGF8 的活性。

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

一种 PI3K 抑制剂,可改变 AKT 通路信号,并可通过改变细胞稳态激活 FGF8 信号。

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

MAPK 通路中 MEK1/2 的选择性抑制剂;通过阻断该通路,PD98059 可以改变细胞环境,从而激活 FGF8 信号。

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

mTOR 抑制剂可影响 PI3K/AKT 信号传导,并可通过启动细胞代偿反应来激活 FGF8 信号传导。

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

一种 p38 MAPK 抑制剂,可改变 MAPK 通路,从而可能以激活 FGF8 信号的方式改变细胞环境。

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$65.00
$267.00
257
(3)

作为 MAPK 通路一部分的 JNK 抑制剂;这种应激反应通路的改变可能会激活 FGF8 信号。

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$182.00
$693.00
88
(1)

ROCK 抑制剂可影响细胞骨架动力学,并可通过改变细胞结构激活 FGF8 信号。

SL-327

305350-87-2sc-200685
sc-200685A
1 mg
10 mg
$107.00
$332.00
7
(0)

MEK 抑制剂通过改变 MAPK 信号,可激活对 FGF8 的调节。

GSK 2334470

1227911-45-6sc-364501
sc-364501A
10 mg
50 mg
$195.00
$1142.00
1
(0)

PDK1 是 AKT 上游激酶的特异性抑制剂;通过改变 AKT 信号,它可以激活 FGF8 信号。