FGF-8F Inhibitors
FGF-8F inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the FGF-8F isoform, a member of the fibroblast growth factor (FGF) family. FGF-8F is one of several isoforms produced by alternative splicing of the FGF-8 gene, and it plays a crucial role in various biological processes, including embryonic development, cell growth, and differentiation. The FGF family is known for its involvement in complex signaling pathways that regulate cell behavior, and FGF-8F, in particular, has been implicated in the regulation of tissue development and the maintenance of certain cellular functions. By inhibiting FGF-8F, researchers can explore the specific roles this isoform plays in these processes, offering insights into its unique contributions compared to other FGF isoforms.
The use of FGF-8F inhibitors in scientific research allows for a detailed examination of the molecular mechanisms underlying FGF-8F's functions. By blocking its activity, scientists can observe the effects on cellular signaling pathways and identify the downstream targets and interactions that are influenced by FGF-8F. This approach helps to delineate the specific pathways through which FGF-8F exerts its effects, distinguishing it from other FGF family members and providing a clearer picture of its role in biological systems. Additionally, the study of FGF-8F inhibitors can contribute to a better understanding of how this isoform interacts with its receptors and other signaling molecules, shedding light on its involvement in various physiological processes. Overall, FGF-8F inhibitors are valuable tools for unraveling the complexities of FGF signaling and for advancing our knowledge of how specific isoforms contribute to the regulation of cellular and developmental processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $47.00 $143.00 $680.00 | 16 | |
PD173074 is a potent and selective FGFR inhibitor that directly targets the tyrosine kinase domain, preventing autophosphorylation and downstream signaling. By inhibiting FGFR, PD173074 disrupts FGF-mediated pathways, impeding cellular processes regulated by FGF such as proliferation and angiogenesis. | ||||||
SU 5402 | 215543-92-3 | sc-204308 sc-204308A | 1 mg 5 mg | $63.00 $98.00 | 36 | |
SU5402 is a small molecule inhibitor of FGFR tyrosine kinase activity. It interferes with the ATP-binding site of FGFR, preventing autophosphorylation and downstream signaling. Through direct inhibition of FGFR, SU5402 disrupts FGF-mediated pathways, impacting cellular responses related to cell growth, differentiation, and angiogenesis. | ||||||
AZD4547 | 1035270-39-3 | sc-364421 sc-364421A | 5 mg 10 mg | $198.00 $309.00 | 6 | |
AZD4547 is a selective FGFR inhibitor that hinders FGFR autophosphorylation and downstream signaling. By targeting the kinase domain, AZD4547 directly inhibits FGFR, disrupting FGF-mediated cellular processes including proliferation and angiogenesis. This compound represents a specific approach to modulating FGF activity by targeting the FGFR signaling pathway. | ||||||
BGJ398 | 872511-34-7 | sc-364430 sc-364430A sc-364430B sc-364430C | 5 mg 10 mg 50 mg 100 mg | $216.00 $252.00 $594.00 $1009.00 | 4 | |
BGJ398 is an orally active inhibitor of FGFR tyrosine kinases. By binding to the ATP-binding pocket of FGFR, it prevents autophosphorylation and downstream signaling. BGJ398 directly inhibits FGFR, disrupting FGF-mediated pathways and cellular responses related to cell proliferation and angiogenesis. This compound offers a targeted strategy for modulating FGF activity through FGFR inhibition. | ||||||
JNJ-26481585 | 875320-29-9 | sc-364515 sc-364515A | 5 mg 50 mg | $321.00 $1224.00 | ||
JNJ-26481585 is an orally active inhibitor of FGFR tyrosine kinase activity. By binding to the ATP-binding site, it inhibits autophosphorylation and downstream signaling. JNJ-26481585 directly targets FGFR, disrupting FGF-mediated pathways and cellular responses related to cell growth and angiogenesis. This compound offers a specific approach to modulating FGF activity through the inhibition of FGFR signaling. | ||||||