Ferrochelatase Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Methyl Mesoporphyrin IX | 142234-85-3 | sc-396879 sc-396879A | 5 mg 25 mg | $300.00 $1040.00 | 9 | |
N-Methyl Mesoporphyrin IX serves as a potent inhibitor of ferrochelatase, a key enzyme in heme biosynthesis. Its unique structure allows for specific binding interactions with the enzyme's active site, altering the enzyme's conformation and hindering its catalytic activity. The compound's distinct electronic properties facilitate competitive inhibition, impacting the kinetics of heme production. This modulation of ferrochelatase activity can influence various metabolic pathways associated with iron and porphyrin metabolism. | ||||||
Deferoxamine | 70-51-9 | sc-507390 | 5 mg | $255.00 | ||
Deferoxamine chelates iron and indirectly inhibits ferrochelatase by reducing the availability of iron for heme synthesis. This indirect inhibition disrupts the final step of heme biosynthesis, potentially affecting cellular processes reliant on heme production and modulation of ferrochelatase activity through the cellular iron pool. | ||||||
DMSA (Meso-2,3-dimercaptosuccinic acid) | 304-55-2 | sc-204732 sc-204732A | 1 g 5 g | $38.00 $94.00 | 1 | |
DMSA, a chelating agent, indirectly inhibits ferrochelatase by binding to metals, including zinc, and reducing their availability for heme synthesis. This indirect inhibition disrupts the final step of heme biosynthesis, potentially influencing cellular processes dependent on heme production and modulating ferrochelatase activity through altered metal availability. | ||||||
Deferasirox | 201530-41-8 | sc-207509 | 2.5 mg | $180.00 | 9 | |
Deferasirox is an iron chelator that indirectly inhibits ferrochelatase by sequestering iron and reducing its availability for heme synthesis. This indirect inhibition disrupts the final step of heme biosynthesis, potentially impacting cellular processes relying on heme production and modulating ferrochelatase activity through the regulation of intracellular iron levels. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine, a calcium channel blocker, indirectly inhibits ferrochelatase by reducing the influx of calcium ions, which are essential cofactors for the enzyme. This indirect inhibition disrupts the final step of heme biosynthesis, potentially affecting cellular processes reliant on heme production and modulating ferrochelatase activity through altered calcium homeostasis within the cell. | ||||||
4,4′-Bipyridyl | 553-26-4 | sc-256837 sc-256837A sc-256837B | 5 g 25 g 100 g | $33.00 $82.00 $165.00 | ||
4,4'-Bipyridyl chelates metals, including iron, and indirectly inhibits ferrochelatase by sequestering iron and reducing its availability for heme synthesis. This indirect inhibition disrupts the final step of heme biosynthesis, potentially impacting cellular processes dependent on heme production and modulating ferrochelatase activity through altered metal availability. | ||||||
Gadolinium(III) chloride | 10138-52-0 | sc-224004 sc-224004A | 5 g 25 g | $153.00 $357.00 | 4 | |
Gadolinium chloride inhibits ferrochelatase indirectly by interfering with cellular processes dependent on calcium ions, essential cofactors for the enzyme. This indirect inhibition disrupts the final step of heme biosynthesis, potentially influencing cellular processes reliant on heme production and modulating ferrochelatase activity through the alteration of calcium homeostasis within the cell. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese chloride inhibits ferrochelatase by interfering with metal ion cofactors. This direct inhibition disrupts the final step of heme biosynthesis, potentially affecting cellular processes reliant on heme production and modulating ferrochelatase activity through the alteration of metal ion concentrations within the cell. | ||||||
Tin Protoporphyrin IX dichloride | 14325-05-4 | sc-203452 sc-203452A sc-203452B | 5 mg 25 mg 1 g | $77.00 $263.00 $973.00 | 70 | |
Tin protoporphyrin IX inhibits ferrochelatase directly by binding to the enzyme's active site, preventing the insertion of iron into the protoporphyrin IX substrate. This direct inhibition disrupts the final step of heme biosynthesis, potentially influencing cellular processes dependent on heme production and modulating ferrochelatase activity through the direct blockade of the catalytic site. | ||||||
Gallium(III) chloride | 13450-90-3 | sc-250045 sc-250045A | 5 g 25 g | $100.00 $260.00 | ||
Gallium chloride inhibits ferrochelatase indirectly by interfering with metal ion cofactors. This indirect inhibition disrupts the final step of heme biosynthesis, potentially affecting cellular processes reliant on heme production and modulating ferrochelatase activity through the alteration of metal ion concentrations within the cell. | ||||||