Molecular structure of Tin Protoporphyrin IX dichloride, CAS Number: 14325-05-4
Tin Protoporphyrin IX dichloride (CAS 14325-05-4)
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Alternate Names:
Tin Protoporphyrin IX dichloride is also known as SnPPIX.
Application:
Tin Protoporphyrin IX dichloride is a synthetic, potent heme oxygenase inhibitor that selectively inhibits HO-1 over HO-2.
CAS Number:
14325-05-4
Purity:
≥95%
Molecular Weight:
750.26
Molecular Formula:
C34H32N4O4Sn•2Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tin Protoporphyrin IX dichloride is a metalloporphyrin complex used extensively in research for its role as a heme oxygenase inhibitor. Scientists employ this compound in studies investigating the regulation of heme metabolism and in analyzing the pathophysiology of diseases where heme oxygenase activity is implicated. In photosensitization research, Tin Protoporphyrin IX dichloride aids in understanding the photo-oxidative damage that can occur in biological systems, providing insights into the mechanisms of light-induced tissue damage. Additionally, it serves as useful in the study of circadian rhythm biology due to its effects on the heme pathway, which is known to influence biological clocks. Research in plant biology also utilizes this chemical, exploring its impact on chlorophyll synthesis and heme-containing enzymes, which are vital for plant development and metabolism.
Tin Protoporphyrin IX dichloride (CAS 14325-05-4) References
- Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction. | Clark, JE., et al. 2000. Am J Physiol Heart Circ Physiol. 278: H643-51. PMID: 10666097
- Protection against ozone-induced pulmonary inflammation and cell death by endotoxin pretreatment in mice: role of HO-1. | Li, L., et al. 2000. Inhal Toxicol. 12: 1225-38. PMID: 11203434
- Carbon monoxide and pancreatic islet blood flow in the rat: inhibition of haem oxygenase does not affect islet blood perfusion. | Carlsson, PO., et al. 2006. Scand J Clin Lab Invest. 66: 543-8. PMID: 17101545
- Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress. | Surh, YJ., et al. 2009. Arch Pharm Res. 32: 1163-76. PMID: 19727608
- Up-regulation of heme oxygenase-1 expression through CaMKII-ERK1/2-Nrf2 signaling mediates the anti-inflammatory effect of bisdemethoxycurcumin in LPS-stimulated macrophages. | Kim, AN., et al. 2010. Free Radic Biol Med. 49: 323-31. PMID: 20430097
- Anti-inflammatory effects of Amomum compactum on RAW 264.7 cells via induction of heme oxygenase-1. | Lee, JA., et al. 2012. Arch Pharm Res. 35: 739-46. PMID: 22553068
- Antioxidative effect of several porphyrins on lipid peroxidation in rat liver homogenates. | Imai, K., et al. 1990. Chem Pharm Bull (Tokyo). 38: 258-60. PMID: 2337947
- Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages. | Melief, SM., et al. 2013. Stem Cells. 31: 1980-91. PMID: 23712682
- The peripheral antinociceptive effect induced by the heme oxygenase/carbon monoxide pathway is associated with ATP-sensitive K+ channels. | Pereira de Ávila, MA., et al. 2014. Eur J Pharmacol. 726: 41-8. PMID: 24457122
- Exenatide induces aortic vasodilation increasing hydrogen sulphide, carbon monoxide and nitric oxide production. | Sélley, E., et al. 2014. Cardiovasc Diabetol. 13: 69. PMID: 24693878
- Cytoprotective effect of β-lapachone by inducing heme oxygenase-1 expression and AMP-activated protein kinase activation in human endothelial cells. | Byun, SJ., et al. 2014. Eur Rev Med Pharmacol Sci. 18: 949-58. PMID: 24763872
- In vitro reversion of activated primary human hepatic stellate cells. | El Taghdouini, A., et al. 2015. Fibrogenesis Tissue Repair. 8: 14. PMID: 26251672
- Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion. | Tong, S., et al. 2015. Hypertension. 66: 1073-81. PMID: 26324507
- Zinc L-carnosine suppresses inflammatory responses in lipopolysaccharide-induced RAW 264.7 murine macrophages cell line via activation of Nrf2/HO-1 signaling pathway. | Ooi, TC., et al. 2017. Immunopharmacol Immunotoxicol. 39: 259-267. PMID: 28697633
- Leishmania donovani Exploits Macrophage Heme Oxygenase-1 To Neutralize Oxidative Burst and TLR Signaling-Dependent Host Defense. | Saha, S., et al. 2019. J Immunol. 202: 827-840. PMID: 30593539
- Pathological Significance and Prognostic Roles of Indirect Bilirubin/Albumin Ratio in Hepatic Encephalopathy. | Li, Y., et al. 2021. Front Med (Lausanne). 8: 706407. PMID: 34527681
- Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation. | Zakhary, R., et al. 1996. Proc Natl Acad Sci U S A. 93: 795-8. PMID: 8570637
- Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response. | Cable, EE., et al. 1997. Mol Cell Biochem. 169: 13-20. PMID: 9089626
Inhibitor of:
Ferrochelatase, HCCS, Heme Oxygenase, Heme Oxygenase 2, Heme Oxygenase 3, and Hemoglobin μ.Activator of:
H2-Dd, Hemopexin, and HMBOX1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tin Protoporphyrin IX dichloride, 5 mg | sc-203452 | 5 mg | $75.00 | |||
Tin Protoporphyrin IX dichloride, 25 mg | sc-203452A | 25 mg | $258.00 | |||
Tin Protoporphyrin IX dichloride, 1 g | sc-203452B | 1 g | $954.00 |