Molecular structure of DMSA (Meso-2,3-dimercaptosuccinic acid), CAS Number: 304-55-2
DMSA (Meso-2,3-dimercaptosuccinic acid) (CAS 304-55-2)
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Application:
DMSA (Meso-2,3-dimercaptosuccinic acid) is a water-soluble chelating agent
CAS Number:
304-55-2
Purity:
97%
Molecular Weight:
182.22
Molecular Formula:
C4H6O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DMSA (Meso-2,3-dimercaptosuccinic acid) is a potent lead chelating agent found to be a scavenger of reactive oxygen species (ROS). Murine experiments have shown that this compound also lowers blood pressure in rat arterial hypertension via a decrease in total cell calcium levels. It has also been observed that DMSA upregulates mRNA expression of macrophage-1 antigen, L-, E-, and P-selectin, as well as causing an increase in TNFalpha (tumor necrosis factor-alpha) concentrations in murine lung. Mechanistic studies suggest that DMSA is metabolized into mixed disulfides of cysteine, which are active chelating agents.
DMSA (Meso-2,3-dimercaptosuccinic acid) (CAS 304-55-2) References
- Anti microbial activity of dimercaptosuccinic acid (DMSA): a new chelating agent. | Vineeta, N., et al. 2001. J Indian Soc Pedod Prev Dent. 19: 160-3. PMID: 12396095
- Interaction of dimercaptosuccinic acid (DMSA) with angiotensin II on calcium mobilization in vascular smooth muscle cells. | Kramer, HJ., et al. 2003. Biochem Pharmacol. 65: 1741-6. PMID: 12754110
- Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication. | Graziano, JH., et al. 1992. J Pediatr. 120: 133-9. PMID: 1309865
- Dimercaptosuccinic acid (succimer; DMSA) in inorganic lead poisoning. | Bradberry, S. and Vale, A. 2009. Clin Toxicol (Phila). 47: 617-31. PMID: 19663612
- Use of oral dimercaptosuccinic acid (succimer) in adult patients with inorganic lead poisoning. | Bradberry, S., et al. 2009. QJM. 102: 721-32. PMID: 19700440
- Leukocyte transepithelial migration in lung induced by DMSA functionalized magnetic nanoparticles. | Azevedo, RB., et al. 2011. Cell Adh Migr. 5: 29-33. PMID: 20935452
- meso-2,3-Dimercaptosuccinic acid: chemical, pharmacological and toxicological properties of an orally effective metal chelating agent. | Aposhian, HV. and Aposhian, MM. 1990. Annu Rev Pharmacol Toxicol. 30: 279-306. PMID: 2160791
- Effects of meso-2,3-dimercaptosuccinic acid, potassium iodide and chlorophyll on lead accumulation in male mice. | Xie, Y. and Zhou, G. 2017. Int J Occup Med Environ Health. 30: 87-93. PMID: 28220909
- Comparative assessment of the effects of meso-2,3-dimercaptosuccinic acid and salinomycin on spleen function of cadmium-exposed mice. | Kamenova, K., et al. 2019. Environ Sci Pollut Res Int. 26: 33304-33310. PMID: 31520384
- Comparative study on the effects of salinomycin, monensin and meso-2,3-dimercaptosuccinic acid on the concentrations of lead, calcium, copper, iron and zinc in lungs and heart in lead-exposed mice. | Ivanova, J., et al. 2020. J Trace Elem Med Biol. 58: 126429. PMID: 31760328
- Metabolism of meso-2,3-dimercaptosuccinic acid in lead-poisoned children and normal adults. | Asiedu, P., et al. 1995. Environ Health Perspect. 103: 734-9. PMID: 7588486
- Effects of meso-2,3-dimercaptosuccinic acid (DMSA) on methyl mercury-induced teratogenesis in mice. | Sanchez, DJ., et al. 1993. Ecotoxicol Environ Saf. 26: 33-9. PMID: 7691533
- Pharmacokinetics of meso-2,3-dimercaptosuccinic acid in patients with lead poisoning and in healthy adults. | Dart, RC., et al. 1994. J Pediatr. 125: 309-16. PMID: 8040783
- The current role of 2,3-dimercaptosuccinic acid (DMSA) in the management of childhood lead poisoning. | Glotzer, DE. 1993. Drug Saf. 9: 85-92. PMID: 8397892
Inhibitor of:
2900024O10Rik, Catalase, Ferrochelatase, and Metallothionein 1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DMSA (Meso-2,3-dimercaptosuccinic acid), 1 g | sc-204732 | 1 g | $37.00 | |||
DMSA (Meso-2,3-dimercaptosuccinic acid), 5 g | sc-204732A | 5 g | $92.00 |