Molecular structure of N-Methyl Mesoporphyrin IX, CAS Number: 142234-85-3
N-Methyl Mesoporphyrin IX (CAS 142234-85-3)
See product citations (9)
Alternate Names:
21H,23H-porphine-2,18-dipropanoic acid, 8,13-diethyl-3,7,12,17,23-pentamethyl; NMM
Application:
N-Methyl Mesoporphyrin IX is an inhibitor of ferrochelatase
CAS Number:
142234-85-3
Molecular Weight:
580.72
Molecular Formula:
C35H40N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Methyl Mesoporphyrin IX is a natural porphyrin and inhibitor of ferrochelatase which is involved in heme synthesis. N-methyl Mesoporphyrin IX has been used as a turn-on biosensor for target DNA sequences when used in complex with a G-quadruplex-forming sequence fused to a DNA sequence complementary to the target sequence. It has also been used to detect amyloid-β (1-40) (Aβ40) fibrils in vitro and in live PC12 cells overexpressing Aβ. N-methyl Mesoporphyrin displays excitation/emission maxima of 399/610 nm, respectively.
N-Methyl Mesoporphyrin IX (CAS 142234-85-3) References
- Metallation of the transition-state inhibitor N-methyl mesoporphyrin by ferrochelatase: implications for the catalytic reaction mechanism. | Shipovskov, S., et al. 2005. J Mol Biol. 352: 1081-90. PMID: 16140324
- Induction of delta-Aminolevulinic Acid Synthase Activity and Inhibition of Heme Synthesis in Euglena gracilis by N-Methyl Mesoporphyrin IX. | Beale, SI. and Foley, T. 1982. Plant Physiol. 69: 1331-3. PMID: 16662396
- N-Methyl Mesoporphyrin IX Inhibits Phycocyanin, but Not Chlorophyll Synthesis in Cyanidium caldarium. | Beale, SI. and Chen, NC. 1983. Plant Physiol. 71: 263-8. PMID: 16662815
- Interaction of human telomeric DNA with N-methyl mesoporphyrin IX. | Nicoludis, JM., et al. 2012. Nucleic Acids Res. 40: 5432-47. PMID: 22362740
- Optimized end-stacking provides specificity of N-methyl mesoporphyrin IX for human telomeric G-quadruplex DNA. | Nicoludis, JM., et al. 2012. J Am Chem Soc. 134: 20446-56. PMID: 23181361
- A novel enzyme-free and label-free fluorescence aptasensor for amplified detection of adenosine. | Fu, B., et al. 2013. Biosens Bioelectron. 44: 52-6. PMID: 23395723
- A Label-free 'Turn-on' Fluorescence Method for Detecting Mercury Ion in Aqueous Solution Based on N-Methyl Mesoporphyrin IX (NMM)/G-quadruplex DNA. | Zhang, X., et al. 2017. Anal Sci. 33: 165-169. PMID: 28190835
- N-Methyl Mesoporphyrin IX as an Effective Probe for Monitoring Alzheimer's Disease β-Amyloid Aggregation in Living Cells. | Li, M., et al. 2017. ACS Chem Neurosci. 8: 1299-1304. PMID: 28281745
- Exploration of Catalytic Nucleic Acids on Porphyrin Metalation and Peroxidase Activity by in Vitro Selection of Aptamers for N-Methyl Mesoporphyrin IX. | Yang, L., et al. 2019. ACS Comb Sci. 21: 83-89. PMID: 30602113
- Surface plasmon resonance study of the interaction of N-methyl mesoporphyrin IX with G-quadruplex DNA. | Perenon, M., et al. 2020. Phys Chem Chem Phys. 22: 4158-4164. PMID: 32039427
- Biophysical and X-ray structural studies of the (GGGTT)3GGG G-quadruplex in complex with N-methyl mesoporphyrin IX. | Lin, LY., et al. 2020. PLoS One. 15: e0241513. PMID: 33206666
- N-methyl mesoporphyrin IX as a highly selective light-up probe for G-quadruplex DNA. | Yett, A., et al. 2019. J Porphyr Phthalocyanines. 23: 1195-1215. PMID: 34385812
- Selection of Aptamer for N-Methyl Mesoporphyrin IX to Develop Porphyrin Metalation DNAzyme. | Yang, L., et al. 2022. Methods Mol Biol. 2439: 15-26. PMID: 35226312
- Label-free fluorescent aptasensor for chloramphenicol based on hybridization chain reaction amplification and G-quadruplex/N-methyl mesoporphyrin IX complexation. | Zheng, W., et al. 2022. RSC Adv. 12: 18347-18353. PMID: 35799942
- Homopurine guanine-rich sequences in complex with N-methyl mesoporphyrin IX form parallel G-quadruplex dimers and display a unique symmetry tetrad. | Ye, M., et al. 2023. Bioorg Med Chem. 77: 117112. PMID: 36508994
Inhibitor of:
Ferrochelatase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Methyl Mesoporphyrin IX, 5 mg | sc-396879 | 5 mg | $256.00 | |||
N-Methyl Mesoporphyrin IX, 25 mg | sc-396879A | 25 mg | $869.00 |