FAM9C Activators
FAM9C activators engage in a variety of signaling mechanisms to enhance the protein's functional activity within cells. For instance, certain small molecules can increase the levels of secondary messengers such as cAMP and cGMP within the cell, thereby activating downstream protein kinases like PKA and PKG. These kinases have broad substrate specificity, and their activation can lead to the phosphorylation of numerous proteins, including FAM9C. Phosphorylation can modulate the activity of FAM9C by altering its conformation, facilitating its interaction with other proteins, or affecting its localization within the cell. Additionally, activators that mimic endogenous ligands or modulate ion levels can trigger signaling cascades that culminate in the activation of kinases like PKC or calcium/calmodulin-dependent kinases. Such kinases play critical roles in transducing signals that regulate cellular functions, potentially influencing the activity of FAM9C by promoting its phosphorylation or integration into multiprotein complexes.
Moreover, there are compounds that can lead to the sustained activation of FAM9C through inhibition of protein phosphatases, which normally act to reverse phosphorylation. The resultant increase in the phosphorylated state of proteins can enhance the activity of FAM9C. Similarly, molecules that induce cellular stress or modulate oxidative states can activate stress-responsive kinases such as JNK, which may indirectly result in the activation of FAM9C through stress-activated signaling pathways. Oxidative agents can also modulate kinase activity, thereby influencing the phosphorylation status and activity of FAM9C.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
A calcium ionophore that increases intracellular calcium levels, potentially activating calcium/calmodulin-dependent protein kinases, which may phosphorylate and activate FAM9C within calcium-dependent signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
As a protein kinase C (PKC) activator, PMA mimics diacylglycerol (DAG) and may initiate phosphorylation cascades that enhance the function of FAM9C by altering its conformation or interaction with other cellular proteins. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
This inhibitor of serine/threonine protein phosphatases leads to sustained phosphorylation of proteins, which may result in increased activity of FAM9C if it is subject to regulation by phosphorylation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Found in green tea, EGCG activates multiple kinase pathways, which could lead to the activation of FAM9C through phosphorylation or other post-translational modifications influenced by kinase activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
A cAMP analog that activates PKA. PKA-mediated phosphorylation could increase the activity of FAM9C by enhancing its functional interactions within the cAMP signaling pathway. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A synthetic sympathomimetic that increases intracellular levels of cAMP, thereby activating PKA, which could phosphorylate and thereby increase the activity of FAM9C within the beta-adrenergic signaling pathway. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Acts as a JNK activator by causing cellular stress. JNK activation may lead to phosphorylation cascades that indirectly increase FAM9C activity within the stress-activated signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cell-permeable cAMP analog that directly activates PKA, potentially enhancing FAM9C activity through PKA-dependent phosphorylation mechanisms. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
A PDE inhibitor that increases cGMP levels, potentially activating cGMP-dependent protein kinases which may phosphorylate and increase the activity of FAM9C. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As a reactive oxygen species, H2O2 can act as a signaling molecule, potentially activating oxidative stress-responsive kinases which may indirectly enhance the function of FAM9C through post-translational modifications. | ||||||