FAM90A1 Activators
Chemical activators of FAM90A1 include a variety of compounds that can induce phosphorylation, a post-translational modification essential for the activation of many proteins. Phorbol 12-myristate 13-acetate (PMA) is one such activator that targets protein kinase C (PKC), a family of enzymes that phosphorylate serine and threonine residues on FAM90A1, thus activating it. Similarly, forskolin acts by increasing levels of cAMP within cells, subsequently activating protein kinase A (PKA), which is known to phosphorylate and activate target proteins including FAM90A1. Ionomycin functions by elevating intracellular calcium levels, which leads to the activation of calmodulin-dependent protein kinases (CaMK). These kinases can then phosphorylate FAM90A1, leading to its activation. The activation of FAM90A1 can also be mediated by epidermal growth factor (EGF), which triggers the MAPK/ERK pathway, known for its role in phosphorylating proteins.
Furthermore, insulin stimulates the PI3K/AKT pathway, resulting in the phosphorylation and activation of a wide array of proteins, including FAM90A1. Hydrogen peroxide, often involved in oxidative signaling processes, can activate intracellular kinases that phosphorylate FAM90A1. Anisomycin, through its activation of stress-activated MAPK pathways such as JNK and p38, also leads to the phosphorylation of FAM90A1. Dibutyryl-cAMP, a synthetic analog of cAMP, activates PKA, which in turn can phosphorylate and activate FAM90A1. Inhibitors like okadaic acid and calyculin A prevent the dephosphorylation of proteins by inhibiting phosphatases, thereby maintaining FAM90A1 in an activated state. Bisindolylmaleimide I, although primarily a PKC inhibitor, can paradoxically activate certain PKC isoforms that phosphorylate FAM90A1. Lastly, S-Nitroso-N-acetylpenicillamine (SNAP) releases nitric oxide, which activates protein kinase G (PKG), a kinase that can phosphorylate and thereby activate FAM90A1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which is known to phosphorylate many substrates, including proteins similar to FAM90A1. Through PKC activation, PMA can enhance phosphorylation of FAM90A1, leading to its activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, thus activating calmodulin-dependent protein kinases (CaMK). These kinases, once activated, can phosphorylate a variety of proteins. CaMK-mediated phosphorylation of FAM90A1 would result in its functional activation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin binding to its receptor stimulates the PI3K/AKT pathway, leading to the phosphorylation of various proteins. AKT kinase, once activated, can phosphorylate FAM90A1, leading to its activation. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide can serve as a signaling molecule that activates intracellular kinases. These kinases can phosphorylate proteins including FAM90A1, leading to its activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates stress-activated MAPK pathways like JNK and p38. These kinases can phosphorylate FAM90A1, leading to its functional activation as a response to stress signaling. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that activates PKA. PKA then phosphorylates multiple targets, including proteins that can be structurally and functionally similar to FAM90A1, thus leading to the activation of FAM90A1. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a phosphatase inhibitor that prevents dephosphorylation of proteins, effectively maintaining proteins in a phosphorylated and activated state. This inhibition can therefore sustain the activated state of FAM90A1. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I, although a PKC inhibitor, can lead to the paradoxical activation of certain PKC isoforms which in turn can phosphorylate and activate FAM90A1. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $74.00 $114.00 $374.00 | 18 | |
SNAP releases nitric oxide which can activate protein kinase G (PKG). PKG phosphorylates serine and threonine residues on target proteins, and the phosphorylation by PKG can lead to the activation of proteins structurally similar to FAM90A1, thereby activating FAM90A1. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), which prevents dephosphorylation of proteins, keeping them in an activated state. By inhibiting PP1 and PP2A, Calyculin A can indirectly maintain the phosphorylation and thus the activation of FAM90A1. | ||||||