FAM80A Inhibitors
Chemical inhibitors of FAM80A function through various mechanisms to disrupt its kinase-like activity and its role in cellular signaling pathways. Bisindolylmaleimide I and Go6983, both protein kinase C (PKC) inhibitors, can inhibit the activity of FAM80A by reducing the overall phosphorylation within the cell that FAM80A might regulate. Similarly, GF109203X targets PKC isoforms and can decrease phosphorylation signaling that FAM80A may use, leading to an inhibition of its function. Staurosporine, a broad-spectrum kinase inhibitor, can interfere with ATP binding sites on kinases, and by competing with ATP for binding, it can inhibit the kinase activity of FAM80A. LY294002 and Wortmannin, as specific phosphoinositide 3-kinases (PI3K) inhibitors, can suppress the PI3K signaling pathway, which can lead to reduced phosphorylation of downstream targets that include substrates of FAM80A, thereby inhibiting its activity.
In addition to these, other inhibitors target different kinases which are part of cellular signaling cascades that FAM80A may influence. PD98059 and U0126, both MEK inhibitors, can disrupt the MAPK/ERK pathway, which is a key regulatory pathway in cells, and this disruption can lead to a reduction in the phosphorylation of proteins that FAM80A acts upon. Similarly, SB203580 and SP600125, which selectively inhibit p38 MAP kinase and c-Jun N-terminal kinase (JNK) respectively, can alter cellular responses to stress and cytokines or transcription factor activity, which may affect the cellular functions regulated by FAM80A, leading to its inhibition. PP2, which selectively inhibits Src family tyrosine kinases, can reduce the phosphorylation levels of proteins that interact with or are substrates of FAM80A, thereby inhibiting its function. Lastly, Rapamycin, an mTOR inhibitor, can impede cellular pathways involving FAM80A by inhibiting a central regulator of cell growth and proliferation, leading to an inhibition of FAM80A's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a potent and selective inhibitor of protein kinase C (PKC). Since FAM80A is a kinase-like protein, by inhibiting PKC, Bisindolylmaleimide I could reduce phosphorylation events within the cell that FAM80A might regulate or depend on for its activity, leading to functional inhibition of FAM80A. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of a wide range of protein kinases. It inhibits kinase activity by binding to the ATP binding sites of these enzymes. Given that FAM80A has a kinase-like domain, Staurosporine could compete with ATP for binding to FAM80A, thus inhibiting its kinase activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). PI3K signaling is crucial for many cellular processes, and the inhibition of PI3K can lead to reduced phosphorylation of downstream targets that may include substrates of FAM80A, thereby inhibiting FAM80A function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor that irreversibly inhibits the enzyme by covalently binding to it. This inhibition can disrupt downstream signaling pathways involving FAM80A, leading to its functional inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK). By inhibiting MEK, PD98059 disrupts the MAPK/ERK pathway, potentially reducing the phosphorylation of proteins that FAM80A may act upon, thus inhibiting the functional activity of FAM80A. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). Inhibition of JNK can alter transcription factor activity and gene expression, which may disrupt cellular functions regulated by FAM80A, resulting in its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. Inhibiting p38 kinase can affect the cellular response to stress and cytokines, potentially disrupting processes that FAM80A is involved in, leading to its functional inhibition. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. Src kinases can phosphorylate a variety of substrates, and inhibiting them with PP2 might reduce the phosphorylation levels of proteins that interact with or are substrates of FAM80A, resulting in functional inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK, which is upstream of ERK in the MAPK pathway. By preventing the activation of ERK through MEK inhibition, U0126 could indirectly inhibit the kinase activity of FAM80A. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. Since mTOR is a central regulator of cell growth and proliferation, by inhibiting mTOR, Rapamycin could impede cellular pathways that FAM80A is involved in, leading to its functional inhibition. | ||||||