FAM44C Inhibitors
Chemical inhibitors of FAM44C can provide insights into its functional role within various signaling pathways by selectively blocking those pathways and observing the resulting effects on FAM44C activity. Staurosporine is known for its broad kinase inhibition profile, which includes the capacity to inhibit protein kinases that may interact with or regulate FAM44C. By blocking these kinases, staurosporine can halt phosphorylation events that FAM44C might facilitate or depend upon for its activity. Similarly, LY294002 and Wortmannin, both inhibitors of phosphoinositide 3-kinases (PI3K), can affect FAM44C by disrupting the PI3K/Akt signaling pathway. If FAM44C functions downstream of PI3K, the use of these inhibitors would attenuate the signal transduction and consequently the activity of FAM44C associated with this pathway.
Further down the signal transduction cascade, inhibitors like PDChemical inhibitors of FAM44C serve as a tool to dissect the signaling pathways in which the protein is involved by selectively blocking these pathways. Staurosporine, a potent protein kinase inhibitor, can disrupt the phosphorylation events that FAM44C may be involved in, effectively reducing its activity by preventing necessary phosphorylation that could be crucial for FAM44C's function. LY294002 and Wortmannin, specific phosphoinositide 3-kinase (PI3K) inhibitors, can diminish FAM44C activity by obstructing the PI3K/Akt pathway, suggesting a role of FAM44C in this signaling cascade. PD98059 and U0126, both inhibitors of MEK, impede the activation of ERK, which, if FAM44C is located downstream, would result in a decrease in FAM44C activity due to the inhibition of the MEK/ERK pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. As FAM44C is a protein that may have kinase activity or interact with kinases in signal transduction, staurosporine inhibits the FAM44C-associated pathways by preventing phosphorylation events that FAM44C might influence or participate in. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). If FAM44C is involved in pathways downstream of PI3K signaling, LY294002 would inhibit the signaling cascade that could involve FAM44C, leading to a decrease in FAM44C's activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinases (ERK). If FAM44C operates in the MEK/ERK pathway, PD98059 would inhibit this pathway, thereby reducing the functional activity of FAM44C. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase. If FAM44C is involved in the p38 MAPK signaling pathway, the use of SB203580 would inhibit this signaling, consequently inhibiting the activity of FAM44C within this pathway. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK, preventing the activation of ERK. If FAM44C functions downstream of the MEK/ERK pathway, U0126 would inhibit the MEK/ERK pathway, thereby inhibiting the function of FAM44C. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). If FAM44C is a part of the JNK signaling pathway, inhibition by SP600125 would suppress the JNK pathway, leading to inhibition of FAM44C's activity within this pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. If FAM44C is involved in the PI3K/Akt pathway, inhibition by Wortmannin would disrupt this pathway, leading to decreased activity of FAM44C. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an inhibitor of Src family kinases. If FAM44C interacts with or is regulated by Src kinases, inhibition by PP2 would disrupt the Src kinase signaling, which in turn would inhibit the function of FAM44C. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum kinase inhibitor with activity against Src family kinases. If FAM44C activity is modulated by Src kinases, Dasatinib would inhibit these kinases and thereby inhibit the functional activity of FAM44C. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR (mechanistic target of rapamycin), which is part of the PI3K/Akt/mTOR pathway. If FAM44C is part of or influenced by this pathway, Rapamycin would inhibit mTOR signaling, leading to functional inhibition of FAM44C's activity. | ||||||