FAM44B Inhibitors
FAM44B inhibitors encompass a range of chemical compounds that target the cellular mechanisms fundamental to the proper biorientation of chromosomes during cell division. These inhibitors primarily exert their effects on the microtubule dynamics and mitotic spindle assembly, which are crucial for the accurate segregation of chromosomes. For instance, certain antimitotic agents stabilize microtubules, preventing their disassembly and thereby disrupting the formation of mitotic spindles. This stabilization hampers the function of proteins like FAM44B, which rely on dynamic microtubules for chromosome alignment and segregation. Other inhibitors bind directly to tubulin, blocking the polymerization of microtubules and consequently the formation of the spindle apparatus. In this way, they indirectly impair FAM44B by undermining the structural integrity of the spindle, essential for chromosome orientation.
Additionally, several compounds inhibit specific kinases such as Aurora kinases and Polo-like kinase 1, which are integral to mitotic checkpoint control and spindle formation. The inhibition of these kinases disrupts the proper chromosomal alignment and segregation, indirectly affecting FAM44B's role in maintaining chromosome orientation during mitosis. Similarly, inhibitors targeting kinesins involved in spindle fiber dynamics can lead to the formation of monopolar spindles, thereby indirectly inhibiting the function of FAM44B. Moreover, the use of selective cyclin-dependent kinase inhibitors can impede cell cycle progression, affecting the proper biorientation process and indirectly leading to the inhibition of FAM44B.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules and prevents their disassembly, which can interrupt cell division and mitotic spindle formation. This disruption can indirectly inhibit FAM44B by affecting its role in the biorientation of chromosomes. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting microtubule polymerization, essential for chromosome segregation. By destabilizing microtubules, colchicine can lead to the inhibition of FAM44B's function in chromosome biorientation. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that impedes spindle fiber formation. This disassembly can indirectly inhibit FAM44B by hampering its function in the alignment and segregation of chromosomes during cell division. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor that disrupts spindle bipolarity by targeting mitotic kinesins, thereby potentially affecting FAM44B's role in maintaining proper chromosome orientation during cell division. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI 2536 is a Polo-like kinase 1 (Plk1) inhibitor that interferes with spindle assembly and chromosome segregation. FAM44B, being involved in chromosome biorientation, may be indirectly inhibited by the prevention of proper spindle function. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor, which disturbs proper chromosomal alignment and segregation. Given FAM44B's involvement in chromosome biorientation, this inhibitor could indirectly affect its function. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-trityl-L-cysteine is a mitotic kinesin Eg5 inhibitor, which leads to the formation of monopolar spindles. Its action can indirectly inhibit FAM44B by influencing the proper biorientation of chromosomes in cell division. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib is an Aurora A kinase inhibitor, which plays a crucial role in the mitotic checkpoint. Inhibition of Aurora A kinase can indirectly inhibit FAM44B due to its involvement in chromosome orientation and segregation. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin, inhibiting microtubule formation, which is essential for mitotic spindle assembly. This action can lead to the indirect inhibition of FAM44B's contribution to chromosome biorientation. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
Purvalanol A is a selective inhibitor of cyclin-dependent kinases, which are pivotal in cell cycle progression. By impeding these kinases, it may indirectly inhibit FAM44B by affecting the process of chromosome biorientation. | ||||||