FAM183A Inhibitors
FAM183A inhibitors belong to a class of compounds primarily targeting key cellular signaling pathways. These inhibitors, represented by chemicals such as Staurosporine, Wortmannin, and U0126, exert their effects by interfering with the activation and functioning of FAM183A indirectly. Staurosporine, for example, acts as a broad-spectrum kinase inhibitor, disrupting the phosphorylation of FAM183A and impeding its activation. Wortmannin and LY294002, both PI3K inhibitors, influence pathways associated with FAM183A, hindering its activation by disrupting PI3K-related cascades.
Additionally, inhibitors like SB 203580, PD98059, and Rapamycin target specific kinases within MAPK and mTOR pathways, intersecting with FAM183A signaling. Bisindolylmaleimide I, a PKC inhibitor, and SB 431542, a TGF-β receptor inhibitor, indirectly impact FAM183A by modulating PKC and TGF-β pathways, respectively. Moreover, compounds like PI-103 act as dual inhibitors of PI3K and mTOR, providing a comprehensive approach to disrupt multiple signaling pathways associated with FAM183A. These inhibitors collectively contribute to the intricate network of cellular processes, offering potential avenues for studying the regulation and functions of FAM183A in a broader context.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent protein kinase inhibitor, targeting a wide range of kinases. It can inhibit FAM183A by interfering with its phosphorylation and subsequent activation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin acts as a phosphoinositide 3-kinase (PI3K) inhibitor. Since FAM183A is implicated in PI3K-related pathways, wortmannin can disrupt these cascades, indirectly inhibiting FAM183A. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 inhibits p38 mitogen-activated protein kinase (MAPK), which intersects with FAM183A signaling. Its action on the MAPK pathway may disrupt FAM183A activation and downstream functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, impacting pathways associated with FAM183A. By preventing PI3K activity, it indirectly suppresses FAM183A activation and its involvement in cellular processes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of extracellular signal-regulated kinases (ERK1/2). As FAM183A is linked to the ERK pathway, U0126 can hinder FAM183A activation by disrupting the signaling through this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits c-Jun N-terminal kinase (JNK), affecting pathways interconnected with FAM183A. Its interference with JNK signaling can indirectly modulate FAM183A activity and downstream effects. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, disrupting the mTOR signaling pathway. Since FAM183A is associated with mTOR, rapamycin can indirectly inhibit FAM183A by interfering with its upstream regulatory pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits MEK1, a kinase upstream of ERK1/2. By disrupting the MEK-ERK pathway, PD98059 indirectly inhibits FAM183A activation, impeding its involvement in cellular processes. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
This compound is a selective protein kinase C (PKC) inhibitor. Since FAM183A is modulated by PKC-related pathways, Bisindolylmaleimide I can indirectly inhibit FAM183A by interfering with PKC signaling. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB 431542 is a transforming growth factor-beta (TGF-β) receptor inhibitor. As FAM183A is influenced by TGF-β pathways, SB 431542 can indirectly inhibit FAM183A by disrupting its regulatory signaling. | ||||||