FAM175B Inhibitors
The chemical inhibitors that target FAM175B function primarily focus on disrupting the protein's role in DNA damage response and repair pathways. LY294002 and Wortmannin, as PI3K inhibitors, indirectly suppress FAM175B by hampering PI3K-related signaling, which is critical for cellular processes including the DNA repair mechanisms that FAM175B is associated with. Similarly, U0126 and PD98059, which are selective inhibitors of MEK1/2, may reduce FAM175B's activity by influencing the MAPK/ERK pathway and altering the protein's involvement in responding to DNA damage. Moreover, inhibitors like SB203580 and SP600125, targeting p38 MAPK andJNK respectively, also contribute to the diminished function of FAM175B by affecting the stress response and apoptotic signaling pathways that are intertwined with DNA damage repair processes where FAM175B operates.
Additionally, compounds such as KU-55933, NU7441, and VE-821 disrupt upstream regulators of DNA repair, namely ATM, DNA-PK, and ATR, which are essential for the accurate orchestration of the cell's response to DNA damage. The indirect inhibition of FAM175B through these compounds could lead to a compromised DNA repair pathway, potentially reducing the efficiency of the processes that FAM175B is involved in. Furthermore, Mirin, by targeting the MRN complex, and Olaparib, a PARP inhibitor, both indirectly affect FAM175B's role in DNA repair by disrupting the recognition and repair of DNA damage, which is a fundamental cellular defense against genomic instability. AZD7762, as a checkpoint kinase inhibitor, further exemplifies the strategy of indirectly inhibiting FAM175B by targeting the checkpoint kinases CHK1 and CHK2, which are pivotal in initiating DNA repair mechanisms that FAM175B is likely involved in. These inhibitors collectively demonstrate a targeted approach to inhibiting FAM175B's function by impeding various signaling pathways and cellular processes that are crucial for the protein's activity in maintaining genomic integrity.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor. FAM175B functions in DNA damage response and PI3K contributes to signaling cascades relevant to cell survival and DNA repair. Inhibition of PI3K activity by LY294002 could indirectly suppress FAM175B function in DNA repair processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another potent PI3K inhibitor. Similar to LY294002, its inhibition of PI3K can indirectly reduce the activity of FAM175B by impacting cellular responses to DNA damage and repair mechanisms. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a specific inhibitor of MEK, which acts upstream of MAPK/ERK. FAM175B's role in signaling could be impacted indirectly by the inhibition of MEK, which may affect the DNA damage response pathways where FAM175B is involved. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of both MEK1 and MEK2. By inhibiting MEK enzymes, this compound can potentially impair signaling pathways that involve FAM175B, particularly in the context of responses to DNA damage. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. Since p38 MAPK is a key player in the cellular stress response, its inhibition by SB203580 could lead to an indirect reduction of FAM175B activity by affecting the stress response pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). By blocking JNK signaling, which is involved in apoptosis and DNA damage repair, SP600125 could indirectly influence FAM175B's functional role in these processes. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
KU-55933 is an inhibitor of ATM, a key regulator of the cellular response to DNA damage. Inhibiting ATM with KU-55933 could indirectly affect FAM175B's role in DNA repair by disrupting upstream signaling. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
NU7441 is a potent inhibitor of DNA-PK, which is involved in the non-homologous end joining (NHEJ) pathway of DNA repair. FAM175B, involved in DNA repair processes, could be indirectly affected by the inhibition of DNA-PK activity. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE-821 is a selective inhibitor of ATR, which is involved in the response to DNA replication stress. By inhibiting ATR, VE-821 could indirectly impair FAM175B's involvement in DNA replication and repair pathways. | ||||||
MRN-ATM Pathway Inhibitor, Mirin | 299953-00-7 | sc-203144 | 10 mg | $138.00 | 4 | |
Mirin is an inhibitor of the Mre11-Rad50-Nbs1 (MRN) complex, which is crucial for DNA damage recognition and repair. This inhibition could indirectly affect FAM175B's role in DNA repair by disrupting the function of the MRN complex. | ||||||