FAM159B Inhibitors
Chemical inhibitors of Shisa like 2B can interact with various signaling pathways to modulate the protein's function within cells. LY294002 and ZSTK474, for example, target PI3K, leading to reduced activity of AKT, a kinase downstream of PI3K. This can impact the stability or localization of Shisa like 2B by altering the cellular signals that typically maintain its functional state. Similarly, Wortmannin and Triciribine also inhibit PI3K and AKT, respectively, further contributing to the downregulation of AKT signaling and subsequent effects on the protein's function. On a different pathway, Rapamycin and PP242 exert their effects by selectively inhibiting the mTOR complexes, which are central to protein synthesis and cellular growth processes. Inhibition of these complexes can result in decreased availability of Shisa like 2B in the cellular environment by reducing the overall protein synthesis machinery that would normally produce and maintain it.
SB203580 and SP600125 focus on stress response pathways by inhibiting p38 MAP kinase and JNK, respectively. The inhibition of these kinases can alter the cellular response to stress and influence Shisa like 2B regulatory mechanisms that might be stress-activated. PD98059 and U0126, both MEK inhibitors, prevent the activation of ERK, a kinase involved in numerous signaling pathways. This can limit the phosphorylation and activation of proteins that play a role in regulating the function of Shisa like 2B. Dasatinib inhibits SRC family tyrosine kinases, which can lead to reduced activity in downstream pathways that are involved in the regulation of Shisa like 2B. Palbociclib, by inhibiting CDK4/6, can influence cell cycle progression, which can indirectly affect the functionality of Shisa like 2B through alterations in cell cycle-dependent regulatory mechanisms. Collectively, these chemical inhibitors can modulate the activity and availability of Shisa like 2B through diverse mechanisms involving key signaling pathways and regulatory processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
This chemical inhibits PI3K, which is involved in the AKT signaling pathway. Inhibition of PI3K can lead to decreased AKT activity, which may result in the functional inhibition of Shisa like 2B as AKT can regulate protein stability and localization. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key kinase in the mTOR signaling pathway. mTOR inhibition can decrease protein synthesis and can inhibit the function of Shisa like 2B by reducing its availability within the cellular environment. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
This compound inhibits p38 MAP kinase, which can regulate stress responses and signaling. Inhibition of p38 MAPK can lead to altered cellular responses and inhibit Shisa like 2B function by affecting its regulatory mechanisms. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits MEK, which in turn inhibits ERK activation. Since ERK is involved in numerous signaling pathways, inhibition of MEK can lead to a reduction in ERK-mediated phosphorylation events that may inhibit Shisa like 2B function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Similar to PD98059, U0126 inhibits MEK1/2, preventing ERK activation. By doing so, it can inhibit the function of Shisa like 2B by reducing the phosphorylation and activation of proteins that regulate its activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
By inhibiting JNK, SP600125 can affect the JNK signaling pathway, which is involved in cellular stress responses. Inhibition of JNK can lead to functional inhibition of Shisa like 2B by impacting its stress-associated regulatory functions. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is a selective inhibitor of mTORC1 and mTORC2. Inhibition of these complexes can decrease protein synthesis and inhibit the function of Shisa like 2B by reducing the cellular processes that contribute to its function. | ||||||
ZSTK 474 | 475110-96-4 | sc-475495 | 5 mg | $75.00 | ||
This compound inhibits PI3K, leading to reduced AKT signaling. Inhibition of this pathway can inhibit the function of Shisa like 2B by decreasing the signaling that maintains its stability or localization. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor, and by inhibiting this kinase, it can result in decreased AKT activity. This can lead to functional inhibition of Shisa like 2B by impacting the signaling pathways that control its function. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib inhibits CDK4/6, which are involved in cell cycle regulation. Inhibition of CDK4/6 can indirectly inhibit the function of Shisa like 2B by altering cell cycle progression and associated regulatory mechanisms. | ||||||