FAM152A Inhibitors
Chemical inhibitors of FAM152A operate by targeting various signaling pathways that are crucial for the regulation of this protein's function within cellular processes. Staurosporine and Bisindolylmaleimide I are examples of kinase inhibitors that directly inhibit protein kinase C (PKC). The inhibition of PKC by these compounds can lead to a reduction in phosphorylation of downstream targets, thereby decreasing the functional activity of FAM152A. Similarly, LY294002 and Wortmannin exert their inhibitory effects on FAM152A by targeting phosphoinositide 3-kinases (PI3K), which are essential components of the signaling pathways that govern cell survival and apoptosis. By inhibiting PI3K, these chemicals can effectively reduce the activity of proteins that interact with and regulate the function of FAM152A.
In addition to these, PD98059 and U0126 focus on the inhibition of the mitogen-activated protein kinase (MAPK) pathway by selectively targeting MEK1/2, an upstream regulator of the extracellular signal-regulated kinases (ERK). This targeted inhibition can diminish the signaling to proteins associated with FAM152A, reducing its activity. Another MAPK pathway component, p38, can be inhibited by SB203580, which may lead to decreased activity of FAM152A-regulating proteins. The JNK pathway, which is also under the MAPK umbrella, can be inhibited by SP600125, thereby preventing the activation of proteins that regulate FAM152A. Y-27632, another chemical in this selection, inhibits the Rho-associated kinase (ROCK), and as ROCK is involved in the organization of the cytoskeleton, which can influence survival signaling, the activity of FAM152A can be decreased by this inhibitor. PP2 and Dasatinib inhibit Src family kinases, and by inhibiting Src, the activity of FAM152A can also be reduced. Lastly, Erlotinib, which inhibits the epidermal growth factor receptor (EGFR) tyrosine kinase, can suppress the EGFR signaling pathways that have downstream effects on the regulation of FAM152A. Overall, these inhibitors collectively target multiple points within the regulatory networks that control the function and activity of FAM152A.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC which is linked to the regulation of cell death and survival pathways that FAM152A is involved in. Staurosporine inhibition of PKC can lead to decreased phosphorylation of downstream targets, potentially reducing the functional activity of FAM152A. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I specifically inhibits PKC, which is known to regulate apoptosis and cell survival. By inhibiting PKC, the signaling cascades that could regulate FAM152A activity are interrupted, leading to inhibition of FAM152A. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K signaling is crucial for a variety of cellular functions, and its inhibition can lead to reduced activity of downstream targets, including those that may interact with FAM152A, resulting in its functional inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3K, which is upstream of cell survival and apoptosis pathways involving FAM152A. The inhibition of PI3K by Wortmannin can lead to decreased activity of proteins that regulate FAM152A function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which acts upstream of ERK in the MAPK pathway. The MAPK pathway is implicated in cell proliferation and survival, and inhibition of MEK by PD98059 can lead to reduced signaling to proteins like FAM152A, inhibiting its activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which are upstream of the ERK pathway involved in cell cycle and survival. Inhibition of MEK1/2 by U0126 can diminish the activity of downstream proteins including potentially FAM152A. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase, which is involved in stress-activated pathways and cytokine production. By inhibiting p38, SB203580 can inhibit the activity of downstream targets that may regulate FAM152A. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, which is part of the MAPK pathway. Inhibition of JNK can prevent the activation of downstream proteins that could interact with and regulate FAM152A, leading to its inhibition. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor, and since ROCK signaling is involved in cytoskeleton organization, which can influence cell survival signaling, its inhibition by Y-27632 could lead to a decrease in FAM152A activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src family kinase inhibitor. Src kinases are involved in various signaling pathways, including those regulating cell survival. Inhibition of Src by PP2 can lead to inhibition of FAM152A through these pathways. | ||||||