FAM12B Inhibitors
The functional activity of FAM12B can be indirectly inhibited through the disruption of various signaling pathways that are crucial for its regulation and activity. Kinase inhibitors such as those that target multiple protein kinases can impede phosphorylation processes, which are vital for the functional activity of numerous proteins. When these phosphorylation cascades are disrupted, proteins that require phosphorylation for their activity, like FAM12B, experience a decrease in their functional capacity. Similarly, inhibitors of the PI3K/Akt signaling pathway, by preventing the activation of downstream targets, lead to a reduction in the phosphorylation and, consequently, the activity of proteins associated with this pathway. This indirect approach to inhibition extends to the blocking of mTORC1 signaling, which can curtail protein synthesis and affect proteins regulated by or downstream of this pathway.
Further mechanisms of indirect inhibition include the interference with the MAPK/ERK pathway using specific MEK inhibitors, which can hinder the phosphorylation and subsequent function of proteins modulated by ERK signaling, potentially impacting FAM12B. Inhibitors of p38 MAP kinase and JNK also contribute to this multifaceted approach by affecting cellular responses to stress and inflammatory signals, potentially reducing the activity of proteins linked to these responses. Additionally, proteasome inhibitors cause the accumulation of polyubiquitinated proteins, which may affect the stability and function of a range of proteins including FAM12B. Cyclin-dependent kinaseinhibitors and SERCA pump inhibitors also play a role by disrupting cell cycle-related signaling and calcium homeostasis, respectively. These disruptions can indirectly lead to the inhibition of proteins that are regulated by mechanisms such as cell cycle-dependent phosphorylation or calcium-dependent processes.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
This kinase inhibitor acts on multiple protein kinases that are crucial for various signaling pathways. It indirectly leads to the inhibition of FAM12B by disrupting the phosphorylation processes that are necessary for its functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
This is a PI3K inhibitor that affects the PI3K/Akt signaling pathway. By inhibiting this pathway, it can decrease the phosphorylation of downstream targets, which may include FAM12B, thereby reducing its activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor, Wortmannin leads to the inhibition of the PI3K/Akt pathway. This inhibition can diminish the phosphorylation and activation of proteins associated with this pathway, including FAM12B, thus indirectly inhibiting its function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that disrupts the mTORC1 signaling pathway. This can lead to decreased protein synthesis and indirectly inhibit proteins that are downstream or regulated by this pathway, potentially including FAM12B. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MEK inhibitor that blocks the MAPK/ERK pathway. By inhibiting this pathway, PD 98059 can indirectly hinder the phosphorylation and function of proteins regulated by ERK, which could include FAM12B. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
This inhibitor targets MEK1/2, leading to downregulation of the MAPK/ERK signaling. As a result, proteins that are phosphorylated by ERK may have reduced activity, including potentially FAM12B. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A specific inhibitor of p38 MAP kinase, affecting the cellular response to stress and inflammatory signals. Through this inhibition, it may indirectly decrease the activity of proteins involved in these signaling pathways, like FAM12B. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK signaling pathway, which modulates cellular responses such as apoptosis and differentiation. By inhibiting JNK, it could indirectly lead to reduced activity of proteins involved in JNK-mediated processes, potentially including FAM12B. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
This proteasome inhibitor can lead to the accumulation of polyubiquitinated proteins, potentially affecting the stability and function of various proteins including FAM12B, thereby indirectly inhibiting its activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that prevents the degradation of ubiquitinated proteins, indirectly leading to reduced activity of proteins that require proteasomal degradation for regulation, which might include FAM12B. | ||||||