FAM127C Inhibitors
Chemical inhibitors of FAM127C function primarily through the modulation of various signaling pathways and cellular processes that FAM127C is presumed to be involved in. Alsterpaullone, Roscovitine, Olomoucine, and PD0332991 target the cyclin-dependent kinases (CDKs), which are integral for cell cycle control. By inhibiting CDKs, these chemicals can arrest the cell cycle at specific checkpoints, thereby preventing the progression to subsequent phases. This action can indirectly inhibit the function of FAM127C, assuming its role is connected to cell cycle regulation. Specifically, PD0332991's selective inhibition of CDK4/6 may affect the retinoblastoma (Rb) protein pathway, which, in turn, can regulate FAM127C's function relative to cell cycle progression.
Furthermore, inhibitors like SP600125 and SB203580 disrupt kinase signaling cascades involved in stress responses and the inflammatory process by inhibiting JNK and p38 MAPK, respectively. If FAM127C's function is tied to these pathways, its role would be functionally inhibited as a result of these chemical actions. In the realm of growth and survival signaling, LY294002 and Wortmannin, as inhibitors of PI3K, along with Triciribine, an Akt inhibitor, can impede the PI3K/Akt pathway. This action can disrupt the functional role of FAM127C if it is involved in this critical signaling pathway. Similarly, Rapamycin's inhibition of mTOR can have an impact on FAM127C's function, provided there's a connection between FAM127C and the mTOR signaling pathways, which are known to govern cell growth and proliferation. Lastly, U0126, which inhibits MEK1/2, can attenuate the MAPK/ERK signaling pathway, potentially leading to the functional inhibition of FAM127C if it participates in this particular signaling cascade. Sorafenib's broad-spectrum kinase inhibition can also suppress FAM127C's function if it is involved in the processes of cell proliferation and angiogenesis that Sorafenib's targets are known to regulate.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone inhibits cyclin-dependent kinases (CDKs) which are crucial for cell cycle progression. Assuming FAM127C is involved in cell cycle regulation, inhibition of CDKs can lead to cell cycle arrest, indirectly inhibiting FAM127C function. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a CDK inhibitor and may indirectly inhibit FAM127C by preventing phosphorylation events needed for its activity or localization, assuming FAM127C is part of the cell cycle or transcription regulation pathways interacting with CDKs. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Olomoucine is another CDK inhibitor which can disrupt the cell cycle. If FAM127C is implicated in cell cycle progression or checkpoint control, inhibition of CDKs would dysregulate the cycle and indirectly inhibit the functional role of FAM127C. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which is involved in stress response and apoptosis. Assuming FAM127C plays a role in these processes, JNK inhibition can prevent FAM127C from executing its function within these pathways, leading to functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, a key player in inflammatory response and stress. If FAM127C is involved in these signaling pathways, inhibition of p38 MAPK can lead to functional inhibition of FAM127C by preventing its participation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, which may indirectly inhibit FAM127C if it's involved in the PI3K/Akt pathway, crucial for survival and metabolism. Inhibition of this pathway can result in functional disruption of FAM127C's role in these cellular processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor and can indirectly inhibit FAM127C if the protein is part of the PI3K/Akt pathway. By inhibiting this pathway, FAM127C's functional role in cellular survival or growth signaling can be disrupted. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which might functionally inhibit FAM127C if FAM127C is involved in the mTOR signaling pathway, affecting cell growth and proliferation. Inhibition of mTOR would then indirectly inhibit the function of FAM127C. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, and if FAM127C is involved in the MAPK/ERK pathway, this inhibition can lead to functional inhibition of FAM127C by preventing downstream signaling events where FAM127C may play a role. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine inhibits Akt and can functionally inhibit FAM127C if it is involved in the Akt signaling pathway. By inhibiting Akt, it would prevent FAM127C from participating in survival and growth signaling processes. | ||||||