Factor XIII A Activators
The first class of Factor XIII A activators are the compounds that enhance the functional activity of this protein through the cAMP-PKA pathway. This group includes adenosine, epinephrine, arachidonic acid, forskolin, alprostadil, iloprost, and isoproterenol. These compounds either directly or indirectly cause an increase in cAMP levels within the cell. For instance, adenosine, through the activation of A2a adenosine receptor, triggers cAMP production. Similarly, epinephrine binds to the β-adrenergic receptor, leading to a signaling cascade that increases cAMP levels. The elevated cAMP then activates protein kinase A (PKA), which is capable of phosphorylating Factor XIII A, therefore enhancing its functional activity.
The second class of Factor XIII A activators are those compounds that activate this protein via the PLC-Ca2+-calmodulin pathway. These include thrombin, ATP, histamine, bradykinin, and serotonin. These compounds activate different receptors, such as PAR1 (thrombin), P2Y1 (ATP), H1 (histamine), B2 (bradykinin), and 5-HT2 (serotonin). Activation of these receptors leads to the activation of phospholipase C (PLC), which increases intracellular Ca2+ levels. The rise in Ca2+ levels then activates calmodulin, which in turnactivates Factor XIII A, thereby enhancing its functional activity.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine, through the activation of A2a adenosine receptor, triggers cAMP production. The rise in cAMP levels leads to the activation of protein kinase A (PKA), which can phosphorylate Factor XIII A, enhancing its functional activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to the β-adrenergic receptor, triggering a signaling cascade that leads to increased cAMP levels. Increased cAMP can activate PKA, which phosphorylates Factor XIII A, enhancing its functional activity. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
Arachidonic acid is a precursor for prostaglandin E2 (PGE2) synthesis. PGE2 can activate its receptor EP2, increasing cAMP levels. Elevated cAMP activates PKA, which can phosphorylate Factor XIII A, thereby enhancing its functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase that increases cAMP levels. Elevated cAMP leads to the activation of PKA, capable of phosphorylating Factor XIII A, enhancing its functional activity. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $230.00 | ||
Thrombin is a serine protease that activates PAR1 receptor, triggering PLC activation, leading to an increase in intracellular Ca2+. The rise in Ca2+ levels can activate calmodulin, which in turn activates Factor XIII A. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $38.00 $74.00 | 9 | |
ATP can bind to P2Y1 receptor, leading to PLC activation and a subsequent increase in intracellular Ca2+. Increased Ca2+ levels can activate calmodulin, which in turn activates Factor XIII A. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine binds to H1 receptor leading to PLC activation, which increases intracellular Ca2+. The rise in Ca2+ levels activates calmodulin, which in turn activates Factor XIII A. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin activates B2 receptor, triggering PLC activation and subsequent increase in intracellular Ca2+. The rise in Ca2+ levels can activate calmodulin, which in turn activates Factor XIII A. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $520.00 | 3 | |
Serotonin binds to the 5-HT2 receptor, leading to PLC activation and an increase in intracellular Ca2+. Increased Ca2+ levels activate calmodulin, which in turn activates Factor XIII A. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $30.00 $142.00 | 16 | |
Alprostadil is a PGE1 analog that activates the EP2 receptor, leading to an increase in cAMP levels. Elevated cAMP activates PKA, capable of phosphorylating Factor XIII A, enhancing its functional activity. | ||||||