EXOSC (exosome component) Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $199.00 $599.00 | 24 | |
Blocks neutral sphingomyelinase (nSMase) activity, preventing ceramide accumulation and exosome release. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $215.00 $622.00 | 5 | |
Blocks Ras farnesylation, disrupting Ras trafficking to exosomes and inhibiting their secretion. | ||||||
Amiloride, 5-(N,N-Dimethyl)-, hydrochloride | 2235-97-4 | sc-202459 | 5 mg | $230.00 | 7 | |
Blocks acid sphingomyelinase (aSMase), reducing ceramide levels and exosome production via the endosomal pathway. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $76.00 $139.00 | 23 | |
Impairs lipid metabolism by targeting cholesterol trafficking, leading to decreased exosome secretion. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
Inhibits splicing, affecting the composition of exosomes and reducing their release from the parent cell. | ||||||
NSC 319726 | 71555-25-4 | sc-477736 | 10 mg | $159.00 | ||
Disrupts lipid rafts and inhibits the endosomal pathway, thereby reducing exosome biogenesis and secretion. | ||||||
2-Hydroxypropyl-β-cyclodextrin | 128446-35-5 | sc-203461 sc-203461B sc-203461C sc-203461A | 1 g 100 g 500 g 5 g | $52.00 $620.00 $1950.00 $130.00 | 8 | |
Modifies membrane cholesterol organization, impacting exosome release and lipid-dependent processes. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interferes with RNA synthesis, potentially affecting Exosc7 by disrupting the transcription of target RNA molecules. | ||||||
6-Azauridine | 54-25-1 | sc-221082B sc-221082 sc-221082C sc-221082A | 500 mg 1 g 2 g 5 g | $95.00 $156.00 $289.00 $666.00 | ||
Examined for their broad impact on RNA metabolism, which could indirectly affect exosome function. | ||||||