Amiloride, 5-(N,N-Dimethyl)-, hydrochloride (CAS 2235-97-4)
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Amiloride, 5-(N,N-Dimethyl)-, hydrochloride (DMA) is an inhibitor of the Na+-H+ exchanger (NHE) with stronger potency than the parent compound, Amiloride • HCl (sc-3578). Amiloride, 5-(N,N-Dimethyl)-, hydrochloride and other amiloride derivatives have been employed in elucidating the dynamics and activity of the NHE. Inhibition of the NHE by Amiloride, 5-(N,N-Dimethyl)-, hydrochloride was demonstrated to protect against severe ischemia/reperfusion-induced cardiac contractile dysfunction by normalizing tissue Na+ levels and preserving contractile function recovery during reperfusion. 5-(N,N)-Dimethylamiloride Hydrochloride is a potent and selective blocker of selective Na+/H+ exchange (IC50 = 6.9 μM). It exhibits higher efficacy and specificity compared to its analog, amiloride. By inhibiting proliferation and inducing differentiation of HL-60 cells, it displays significant effects in controlling cellular processes.
Amiloride, 5-(N,N-Dimethyl)-, hydrochloride (CAS 2235-97-4) References
- Effect of 5-(N,N-Dimethyl)-amiloride, a specific inhibitor of Na(+)/H(+) exchanger, on the palmitoyl-L-carnitine-induced mechanical and metabolic derangements in the isolated perfused rat heart. | Arakawa, J. and Hara, A. 1999. Pharmacology. 59: 239-48. PMID: 10529656
- Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger. | Mirossay, L., et al. 1999. Physiol Res. 48: 135-41. PMID: 10534017
- Characterization of Na(+)/H(+) antiporter activity in PC-Cl3 thyroid cells. | Vilella, S., et al. 2003. Cell Physiol Biochem. 13: 207-14. PMID: 12876378
- Na(+)-Ca2+ exchange in the isolated cochlear outer hair cells of the guinea-pig studied by fluorescence image microscopy. | Ikeda, K., et al. 1992. Pflugers Arch. 420: 493-9. PMID: 1614822
- Involvement of sodium in the protective effect of 5-(N,N-dimethyl)-amiloride on ischemia-reperfusion injury in isolated rat ventricular wall. | Meng, H. and Pierce, GN. 1991. J Pharmacol Exp Ther. 256: 1094-100. PMID: 2005574
- 786-0 Renal cancer cell line-derived exosomes promote 786-0 cell migration and invasion in vitro. | Chen, G., et al. 2014. Oncol Lett. 7: 1576-1580. PMID: 24765179
- Amiloride and its analogs as tools in the study of ion transport. | Kleyman, TR. and Cragoe, EJ. 1988. J Membr Biol. 105: 1-21. PMID: 2852254
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amiloride, 5-(N,N-Dimethyl)-, hydrochloride, 5 mg | sc-202459 | 5 mg | $230.00 |