Exo1 Activators
The ST2 Activators represent a distinctive class of chemical compounds designed to modulate the functional activity of the ST2 protein. This group of compounds exerts their influence either directly or indirectly by impacting the signaling pathways intricately connected to ST2. Notably, Insulin and Lithium Chloride play pivotal roles in enhancing the activity of the PI3K/Akt pathway, a direct partner in the ST2 signaling cascade. The augmentation of PI3K/Akt activity correlates with heightened functional activity of ST2, underlining the intricate interplay between these molecular components.
In a parallel context, Epidermal Growth Factor (EGF) emerges as a potent activator influencing the ERK/MAPK pathway. This, in turn, has downstream effects on the IL-33/ST2 signaling axis, culminating in the activation of ST2. Anisomycin, acting as a JNK activator, adds another layer to this intricate network by promoting the IL-33/ST2 signaling pathway, thereby contributing to ST2 activation. Additionally, Phorbol 12-myristate 13-acetate (PMA), recognized for its role as a Protein Kinase C (PKC) activator, participates in enhancing the IL-33/ST2 signaling pathway, further fortifying the functional activity of ST2. Forskolin, an adenylate cyclase activator, operates on a different front by elevating cAMP levels. This elevation potentiates the IL-33/ST2 signaling pathway, thereby amplifying the functional activity of ST2. Finally, Bradykinin, a peptide activator, intricately modulates the PLC/IP3 pathway, exerting its influence on the IL-33/ST2 signaling axis and ultimately contributing to the enhanced functional activity of ST2. The orchestrated actions of these ST2 Activators underscore the complexity of molecular interactions in the realm of biochemical regulation, providing valuable insights for further exploration in the modulation of ST2-related pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin is a hormone that stimulates the PI3K/Akt pathway. Activation of this pathway leads to downstream effects including the activation of ST2. As ST2 is a part of this pathway, increased activity of PI3K/Akt can enhance the functional activity of ST2. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride is a GSK3β inhibitor. GSK3β inhibition can potentiate PI3K/Akt signaling. As ST2 is a part of the PI3K/Akt pathway, the enhanced signaling can increase the functional activity of ST2. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a JNK activator. JNK is involved in the IL-33/ST2 signaling pathway. Activation of JNK by Anisomycin can lead to the activation of ST2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). PKC activation can enhance the IL-33/ST2 signaling pathway, leading to the activation of ST2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases cAMP levels. Elevated cAMP levels can potentiate the IL-33/ST2 signaling pathway, thus enhancing the functional activity of ST2. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin is a peptide that activates the PLC/IP3 pathway. This pathway can potentiate the IL-33/ST2 signaling pathway, leading to enhanced functional activity of ST2. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine is a polyamine that can activate the NMDA receptors. Activation of these receptors can enhance the IL-33/ST2 signaling pathway, leading to an increase in the functional activity of ST2. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine activates the cAMP/PKA pathway. The cAMP/PKA pathway can enhance the IL-33/ST2 signaling pathway, leading to the activation of ST2. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is an activator of the TRPV1 receptor. The activation of this receptor can enhance the IL-33/ST2 signaling pathway, leading to the activation of ST2. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid that enhances the activity of the NF-κB pathway. The NF-κB pathway can enhance the IL-33/ST2 signaling pathway, leading to the activation of ST2. | ||||||