Exo1 Inhibitors
Exo1 inhibitors are a class of chemical compounds that target the Exonuclease 1 (Exo1) enzyme, which plays a critical role in DNA metabolism, including DNA repair, replication, and recombination. Exo1 is a 5' to 3' exonuclease that processes DNA by degrading single-stranded DNA (ssDNA) during various cellular mechanisms such as mismatch repair (MMR) and the resection of DNA double-strand breaks. By removing nucleotides from the ends of DNA strands, Exo1 contributes to maintaining genomic integrity and ensuring accurate DNA replication. Inhibitors of Exo1 disrupt these processes by either directly binding to the active site of the enzyme or by inducing conformational changes that reduce its enzymatic activity, thereby preventing the degradation of DNA.
The inhibition of Exo1 can affect several cellular pathways related to DNA maintenance. For instance, by blocking the enzyme's exonuclease activity, Exo1 inhibitors can impair the cell's ability to process DNA damage during repair pathways such as homologous recombination or MMR. This may lead to the accumulation of DNA errors or inhibit the proper repair of breaks, which can trigger alternative DNA repair mechanisms or stall replication forks. Exo1 inhibitors are useful tools for studying the fine regulation of DNA processing events, as Exo1 is involved in the coordination of multiple pathways that maintain chromosomal stability. These inhibitors provide insights into how cells handle DNA damage and replication stress, offering a deeper understanding of the molecular machinery that ensures genome fidelity during cell division and DNA repair processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K). PI3K is upstream of Akt, which is known to regulate IL-33/ST2 signaling. LY294002 can disrupt this pathway by inhibiting PI3K, thus indirectly inhibiting ST2. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor. By inhibiting PI3K, it disrupts the downstream Akt signaling, which can inhibit ST2 by reducing IL-33/ST2 signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MAPK/ERK kinase (MEK). MEK is upstream of ERK1/2, which influences IL-33/ST2 signaling. PD98059 can indirectly inhibit ST2 by disrupting the ERK1/2 signaling pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a potent inhibitor of p38 MAPK. p38 MAPK is involved in the signaling pathway of IL-33/ST2. By inhibiting p38 MAPK, SB203580 can indirectly inhibit ST2. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, a kinase that is involved in the IL-33/ST2 signaling pathway. Inhibition of JNK by SP600125 can lead to the indirect inhibition of ST2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. mTOR is a kinase that is involved in the IL-33/ST2 signaling pathway. By inhibiting mTOR, Rapamycin can indirectly inhibit ST2. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 inhibits IκBα phosphorylation, which is needed for the activation of NF-κB. NF-κB is involved in the IL-33/ST2 signaling pathway, so its inhibition by BAY 11-7082 can indirectly inhibit ST2. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A inhibits calcineurin, a phosphatase involved in the activation of NFAT, which is involved in the IL-33/ST2 signaling pathway. Inhibition of calcineurin leads to the indirect inhibition of ST2. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 also inhibits calcineurin, leading to the inhibition of NFAT and the IL-33/ST2 signaling pathway, which results in the indirect inhibition of ST2. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 (AG 490) is a JAK2 inhibitor. JAK2 is involved in the IL-33/ST2 signaling pathway, and its inhibition by AG 490 can indirectly inhibit ST2. | ||||||