Exendin 4 Activators
Exendin-4 activators, also known as GLP-1 receptor agonists, belong to a class of molecules that play a crucial role in regulating glucose homeostasis and satiety in the human body. These activators are synthetic analogs of the naturally occurring glucagon-like peptide-1 (GLP-1), a hormone produced by the intestines in response to food ingestion. Exendin-4 activators specifically target and activate the GLP-1 receptors on various cells throughout the body, with a primary focus on pancreatic beta cells and neurons in the brain. This activation triggers a cascade of physiological responses that collectively contribute to the control of blood sugar levels and appetite.
When Exendin-4 activators bind to GLP-1 receptors on pancreatic beta cells, they stimulate the release of insulin in a glucose-dependent manner. This means that insulin secretion is enhanced when blood sugar levels are elevated, helping to lower excessive blood glucose levels. Additionally, Exendin-4 activators slow down the rate at which the stomach empties, leading to a feeling of fullness and reduced food intake.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels, enhancing PKA activity. This can upregulate CREB, a transcription factor, which may enhance GLP-1 expression, indirectly affecting Exendin-4. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates Protein Kinase C (PKC), which can modulate the GLP-1 receptor signaling, indirectly influencing Exendin-4 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Influences AMPK pathways, which are involved in glucose metabolism. This modulation can impact GLP-1 activity, thereby affecting Exendin-4. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR pathway, which is linked to insulin signaling and glucose metabolism. This might influence GLP-1 and Exendin-4 indirectly. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Enhances insulin sensitivity through PPARγ activation, which could indirectly affect GLP-1 and Exendin-4. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Influences multiple signaling pathways including NF-κB, which could indirectly affect GLP-1 and Exendin-4. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Acts on AMPK pathway, influencing metabolic processes that could indirectly impact GLP-1 and Exendin-4. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences GSK-3β and other signaling pathways, potentially affecting GLP-1 and Exendin-4 indirectly. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Histone deacetylase inhibitor, can influence gene expression and metabolic pathways indirectly affecting GLP-1 and Exendin-4. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Influences TRPV1 and related metabolic pathways, potentially affecting GLP-1 and Exendin-4 indirectly. | ||||||