ESCO2 Activators
Trichostatin A and Sodium Butyrate, modulates chromatin structure through histone deacetylation inhibition. This alteration in chromatin accessibility can enhance the activity of ESCO2 by facilitating the interaction between cohesin complexes and chromosomal DNA. Similarly, 5-Azacytidine's impact on DNA methylation patterns can also influence the expression of genes critical for sister chromatid cohesion, thereby enhancing ESCO2's function.
Other activators, such as Mimosine, Roscovitine, and Hydroxyurea, exert their influence by modulating cell cycle progression. Mimosine's arrest of cells in the G1 phase, Roscovitine's inhibition of cyclin-dependent kinases, and Hydroxyurea's S phase arrest can all indirectly enhance ESCO2's activity by affecting the timing and dynamics of cohesin complex formation and function. Additionally, compounds like Paclitaxel, Nocodazole, Aphidicolin, Bleomycin, Cisplatin, and Etoposide, which interfere with microtubule dynamics, DNA replication, or cause DNA damage,
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A can modify chromatin structure, potentially enhancing ESCO2 activity by influencing the accessibility of cohesin complexes to chromosomal DNA. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate, also a histone deacetylase inhibitor, can affect chromatin remodeling and thereby potentially enhance the functional activity of ESCO2 in cohesin complex formation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor can lead to demethylation of DNA, potentially affecting the expression of genes involved in sister chromatid cohesion, indirectly enhancing ESCO2 activity. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $36.00 $88.00 $220.00 $436.00 | 8 | |
Mimosine arrests cells at the late G1 phase, which can indirectly affect the activity of ESCO2 by modulating the cell cycle and the timing of cohesin complex formation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
As a cyclin-dependent kinase inhibitor, Roscovitine can influence cell cycle progression, potentially affecting the timing and function of ESCO2 in sister chromatid cohesion. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and can arrest cells in the G2/M phase, which may indirectly affect ESCO2 activity during chromosome segregation. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubules and arrests cells in the M phase. This alteration in cell cycle progression can indirectly affect ESCO2's role in chromosome segregation. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin causes DNA damage, potentially enhancing the functional activity of ESCO2 by increasing the need for accurate chromosome segregation mechanisms. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin induces DNA cross-links and damage, which may indirectly enhance ESCO2 activity by necessitating proper sister chromatid cohesion for DNA repair processes. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide induces DNA double-strand breaks, potentially enhancing ESCO2's activity in maintaining chromosome integrity during cell cycle progression. | ||||||