Ero1-Lα Activators
Ero1-Lα activators encompass a diverse range of chemicals that influence the protein's activity by modulating the cellular and biochemical environments, particularly within the endoplasmic reticulum (ER). These activators do not interact directly with Ero1-Lα but exert their effects through indirect pathways that create conditions conducive to its function. For instance, agents like glucose and glycerol enhance the ER's capacity for protein folding, which in turn can stimulate Ero1-Lα activity, given its role in oxidative protein folding. Similarly, chemicals like hydrogen peroxide and deferoxamine modulate the redox balance within cells, affecting the oxidative environment of the ER, which is crucial for Ero1-Lα's function in forming disulfide bonds in nascent proteins.
Other compounds, such as N-Acetylcysteine and beta-mercaptoethanol, though generally considered reducing agents, can paradoxically enhance the oxidative folding capacity of the ER, leading to increased activity of Ero1-Lα. Calcium ionophores like A23187 elevate intracellular calcium levels, promoting an environment that favors Ero1-Lα activity. Additionally, chemical chaperones such as sodium 4-phenylbutyrate and 4-phenylbutyric acid alleviate ER stress, creating a more favorable environment for Ero1-Lα's function. Finally, micronutrients like zinc and selenium play roles in maintaining cellular redox states, and their presence is integral to the modulation of Ero1-Lα activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $37.00 $194.00 $64.00 | 5 | |
Glucose metabolism can enhance ER function and protein folding capacity. Elevated glucose levels can indirectly stimulate Ero1-Lα activity by increasing the demand for protein folding in the ER. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophores increase intracellular calcium levels, which can enhance ER function. Elevated calcium in the ER can indirectly activate Ero1-Lα by promoting its oxidative environment, crucial for its activity. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
As an oxidizing agent, hydrogen peroxide can enhance the oxidative environment of the ER, indirectly stimulating the activity of Ero1-Lα, which is involved in disulfide bond formation in proteins. | ||||||
Deferoxamine | 70-51-9 | sc-507390 | 5 mg | $250.00 | ||
Deferoxamine chelates iron, which can modulate cellular redox states. Alterations in redox balance can indirectly influence Ero1-Lα activity, as it is sensitive to the redox environment in the ER. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
While known as a reducing agent, N-Acetylcysteine can also modulate redox balance in cells. This modulation can indirectly affect Ero1-Lα activity by altering the ER redox environment. | ||||||
Glycerol | 56-81-5 | sc-29095A sc-29095 | 100 ml 1 L | $55.00 $150.00 | 12 | |
Glycerol functions as a chemical chaperone and osmolyte, stabilizing protein structure and function. This stabilization can indirectly increase Ero1-Lα activity by enhancing overall protein folding efficiency in the ER. | ||||||
β-Mercaptoethanol | 60-24-2 | sc-202966A sc-202966 | 100 ml 250 ml | $88.00 $118.00 | 10 | |
Beta-Mercaptoethanol, as a reducing agent, can paradoxically enhance the oxidative folding capacity of the ER under certain conditions, potentially leading to increased Ero1-Lα activity. | ||||||
4-Phenylbutyric acid | 1821-12-1 | sc-232961 sc-232961A sc-232961B | 25 g 100 g 500 g | $52.00 $133.00 $410.00 | 10 | |
Similar to its sodium salt, 4-Phenylbutyric Acid acts as a chemical chaperone, alleviating ER stress. This can indirectly stimulate Ero1-Lα activity by improving the protein folding environment in the ER. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic Acid, or Vitamin C, is an antioxidant that can modulate the redox state in cells. This modulation can indirectly affect Ero1-Lα by influencing the oxidative environment within the ER. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc can modulate various cellular processes including redox balance. Its influence on cellular redox states can indirectly impact Ero1-Lα activity by affecting the ER redox environment. | ||||||