Ero1-Lα Antibody (D-7): sc-365526

Ero1-Lα Antibody (D-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects Ero1-L alpha protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Ero1-Lα (D-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Ero1-La, also known as endoplasmic oxidoreductin-1-like or ERO1A, plays a critical role in oxidative protein folding within the endoplasmic reticulum, essential for proper protein maturation and function. Ero1-La facilitates disulfide bond formation, a key post-translational modification that stabilizes protein structures, by working with protein disulfide isomerase (PDI). Ero1-La and PDI interaction enables efficient folding of immunoglobulins, crucial for immune response. Hypoxia regulates Ero1-La through the hypoxia-inducible transcription factor pathway, indicating significance in cellular responses to low oxygen levels. While most tissues express low levels of Ero1-La, significantly higher expression occurs in the upper digestive tract and esophagus, suggesting a specialized role in these regions. Ero1-La functions as both a monomer and homodimer, highlighting versatility in cellular processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Ero1-Lα Antibody (D-7) References:

1. Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells.  |  Khoo, C., et al. 2011. Endocrinology. 152: 2599-608. PMID: 21540283
2. The NFIB-ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells.  |  Zilli, F., et al. 2021. EMBO Mol Med. 13: e13162. PMID: 33751828
3. circ-ACACA promotes proliferation, invasion, migration and glycolysis of cervical cancer cells by targeting the miR-582-5p/ERO1A signaling axis.  |  Huang, D. and Li, C. 2021. Oncol Lett. 22: 795. PMID: 34584570
4. Knockdown of PPARδ Induces VEGFA-Mediated Angiogenesis via Interaction With ERO1A in Human Colorectal Cancer.  |  Luo, W., et al. 2021. Front Oncol. 11: 713892. PMID: 34712608
5. Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.  |  Zhou, X., et al. 2023. Life Sci. 327: 121698. PMID: 37080351
6. Suppression of Microglial ERO1a Alleviates Inflammation and Enhances the Efficacy of Rehabilitative Training After Ischemic Stroke.  |  Ren, J., et al. 2023. Mol Neurobiol. 60: 4429-4441. PMID: 37100971
7. Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity.  |  Liu, L., et al. 2023. Cell Rep Med. 4: 101206. PMID: 37769655
8. Inhibition of ERO1a and IDO1 improves dendritic cell infiltration into pancreatic ductal adenocarcinoma.  |  Tay, AHM., et al. 2023. Front Immunol. 14: 1264012. PMID: 38187398
9. SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA.  |  Germani, S., et al. 2024. Cell Rep Med. 5: 101439. PMID: 38402623
10. ERO1A levels are a prognostic indicator in EGFR mutated non small cell lung cancer.  |  Voronkova, MA., et al. 2024. NPJ Precis Oncol. 8: 250. PMID: 39496753

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ero1-Lα Antibody (D-7) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-Ero1-Lα Antibody (D-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ero1-Lα Antibody (D-7) Specifications

Alternate Product Name: ERO1 Alpha

Product Clone Name: D-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 91-180

Epitope Target: Ero1-Lα

Epitope Species: human

Product Reactivity/Detection: Ero1-Lα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for Ero1-Lα Antibody (D-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Ero1-Lα antibody is Ero1-Lα Antibody (YW-8): sc-100805.