eRF3b Inhibitors

The class of eRF3b inhibitors comprises a range of compounds that indirectly influence the activity of eRF3b by targeting various stages of protein synthesis. These inhibitors work by interfering with the process of translation at different points, from initiation to elongation, and ultimately affect the termination phase where eRF3b is functional. The indirect inhibition of eRF3b results from the compromised integrity and efficiency of the translational machinery, essentially reducing the functional workload or altering the context in which eRF3b operates.

These compounds act by binding to specific components of the ribosome or to factors involved in the translation process. Some of these chemicals block the progression of the ribosome along the mRNA, thereby reducing the instances where translation termination would ordinarily occur, and eRF3b would play its role. Others inhibit the formation of the initiation complex or affect the peptidyl transferase activity, leading to a decreased number of ribosomes reaching the termination stage. Furthermore, some compounds induce premature termination, disrupting the normal sequence of events in which eRF3b participates. By altering the translation process through various modes of action, these inhibitors effectively reduce the functional requirement for eRF3b in the cell. The activity of eRF3b is thus indirectly diminished due to the lowered rate of translation termination events or the altered termination environment.