ε-sarcoglycan Inhibitors
-Sarcoglycan inhibitors represent a class of compounds that primarily target ε-sarcoglycan, a transmembrane protein that plays a crucial role in maintaining the structural integrity and function of muscle cells. ε-Sarcoglycan is a member of the sarcoglycan complex, a group of proteins that forms part of the dystrophin-glycoprotein complex (DGC). The DGC is essential for stabilizing the sarcolemma, the cell membrane of muscle cells, and mediating interactions between the extracellular matrix and the cytoskeleton. ε-Sarcoglycan, specifically, is implicated in the formation of the sarcoglycan complex, contributing to the overall stability and function of muscle fibers. Inhibitors of ε-sarcoglycan may exert their effects by modulating the expression, post-translational modification, or interactions of this protein within the complex.
ε-sarcoglycan inhibitors operate requires a comprehensive exploration of the molecular pathways involved in sarcoglycan complex assembly and maintenance. These inhibitors may interfere with the synthesis or assembly of ε-sarcoglycan, impacting the overall architecture of the DGC and subsequently compromising the stability of muscle cell membranes. The targeted modulation of ε-sarcoglycan could have implications for various physiological processes, particularly those related to muscle contraction and mechanical support.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 can inhibit myosin light chain kinase, potentially altering muscle contraction and thereby affecting the mechanical stability that sarcoglycans support. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
This compound is a calmodulin antagonist and by inhibiting calmodulin-dependent processes, it might impact the intracellular signaling that affects ε-sarcoglycan function. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene interferes with ryanodine receptors and could alter calcium homeostasis, indirectly affecting the stability of the sarcoglycan complex. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
As an inhibitor of myosin II, Blebbistatin may affect muscle fiber integrity and thereby the mechanical load on ε-sarcoglycan. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
This is a protein kinase C inhibitor that could alter signaling pathways that indirectly affect ε-sarcoglycan's stability or expression. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
By inhibiting ROCK, this compound can alter cytoskeletal dynamics, potentially influencing ε-sarcoglycan's cellular context. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
As a PI3K inhibitor, Wortmannin may affect various signaling cascades, possibly impacting ε-sarcoglycan indirectly. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
This p38 MAP kinase inhibitor may modulate stress-related signaling pathways that could intersect with ε-sarcoglycan's role in the cell. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Another PI3K inhibitor, LY294002, could alter intracellular signaling, potentially affecting ε-sarcoglycan. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
As an MEK inhibitor, PD 98059 might interfere with signaling pathways relevant to ε-sarcoglycan's role in muscle tissue. | ||||||