Epsilon-COP Inhibitors
Chemical inhibitors of Epsilon-COP disrupt its function in vesicular trafficking within the cell. Brefeldin A targets Epsilon-COP by inhibiting ARF, a GTPase that interacts with Epsilon-COP for the initiation of vesicle formation. This inhibition results in the impairment of Epsilon-COP's role in vesicle formation and maintenance. Similarly, Golgicide A affects the function of Epsilon-COP by directly inhibiting the Sec7 domain of GBF1, a guanine nucleotide exchange factor for ARF1, which is necessary for Epsilon-COP to perform its function in coat protein I vesicle formation. Exo1 operates by inhibiting the GDP-GTP exchange on ARF1, a process crucial for the assembly of the coatomer complex that includes Epsilon-COP, thereby hindering vesicular trafficking processes that Epsilon-COP facilitates.
Other chemicals interfere with Epsilon-COP's function by targeting different aspects of the cellular machinery involved in vesicle trafficking. AG1478 indirectly inhibits Epsilon-COP by targeting tyrosine kinases, which are part of signaling pathways that affect vesicle trafficking. Dynasore serves to disrupt the function of Epsilon-COP by inhibiting dynamin, which is critical for vesicle scission from the Golgi apparatus, where Epsilon-COP operates. Latrunculin A and Cytochalasin D disrupt the actin cytoskeleton, which is essential for vesicle movement and maintenance, thus impairing Epsilon-COP's ability to facilitate efficient vesicle trafficking. Nocodazole, Colchicine, and Vinblastine disrupt microtubule dynamics by inhibiting polymerization or inducing depolymerization, which can inhibit Epsilon-COP's role in microtubule-dependent vesicle transport. Lastly, Paclitaxel stabilizes microtubules, preventing their disassembly, which is also critical for vesicle trafficking involving Epsilon-COP, while Monensin disrupts ionic gradients critical for vesicle acidification and maintenance, indirectly affecting Epsilon-COP's function in vesicle formation.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A inhibits ADP-ribosylation factor (ARF), a small GTPase that Epsilon-COP interacts with for vesicle formation. Inhibition of ARF disrupts the recruitment of Epsilon-COP to membranes, leading to inhibition of Epsilon-COP function in vesicular trafficking. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $191.00 $683.00 | 11 | |
Golgicide A directly inhibits the coatomer protein complex by targeting the Sec7 domain of GBF1, a GEF for ARF1, which Epsilon-COP interacts with. This results in disassembly of the coatomer complex, thereby inhibiting Epsilon-COP function in coat protein I (COPI) vesicle formation. | ||||||
Exo1 | 461681-88-9 | sc-200752 sc-200752A | 10 mg 50 mg | $84.00 $297.00 | 4 | |
Exo1 inhibits the exchange of GDP for GTP on ARF1, which is required for coatomer complex assembly that includes Epsilon-COP. By inhibiting this exchange, Exo1 indirectly inhibits Epsilon-COP function in vesicular trafficking. | ||||||
Tyrphostin AG 1478 | 175178-82-2 | sc-200613 sc-200613A | 5 mg 25 mg | $96.00 $421.00 | 16 | |
AG1478 is a tyrosine kinase inhibitor that can indirectly inhibit Epsilon-COP by inhibiting EGF receptor signaling, which can downstream affect vesicle trafficking and membrane dynamics that Epsilon-COP is involved in. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore inhibits dynamin, which is involved in vesicle scission from the Golgi. Since Epsilon-COP is involved in vesicle formation, inhibiting dynamin indirectly disrupts the vesicle trafficking process in which Epsilon-COP participates. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to actin monomers and prevents polymerization, which is critical for maintaining cytoskeleton integrity and vesicle movement. Disruption of actin dynamics can inhibit Epsilon-COP function by impairing vesicle trafficking. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts actin filaments by capping their growing ends. Since Epsilon-COP is involved in trafficking that relies on the cytoskeleton, this disruption can inhibit the vesicular transport processes involving Epsilon-COP. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which can indirectly inhibit Epsilon-COP by affecting microtubule-dependent vesicle transport where Epsilon-COP plays a role in vesicle tethering and fusion. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin and inhibits its polymerization, disrupting microtubule dynamics. This can inhibit Epsilon-COP as it is involved in microtubule-dependent vesicle trafficking within the cell. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin and prevents microtubule assembly, which is necessary for transport processes that Epsilon-COP is involved in, indirectly inhibiting Epsilon-COP's function in vesicle trafficking. | ||||||