Eps15L1 Inhibitors
Eps15L1 inhibitors encompass a range of chemical compounds that interfere with various stages of the endocytic pathway, a primary cellular mechanism where Eps15L1Eps15L1 inhibitors encompass a range of chemical compounds that interfere with various stages of the endocytic pathway, a primary cellular mechanism where Eps15L1 is known to operate. Wortmannin and MiTMAB exemplify this by inhibiting key molecules like PI3K and dynamin, respectively, which are crucial for the endocytic functions of Eps15L1. The inhibition of PI3K by Wortmannin impedes the formation of phosphoinositides necessary for endocytic vesicle formation, thereby hampering the recruitment of Eps15L1 to endocytic sites. Similarly, MiTMAB's inhibition of dynamin affects vesicle scission, a critical step where Eps15L1 is involved. The blockage of this process by MiTMAB results in a functional inhibition of Eps15L1, as it cannot participate in the release of newly formed endocytic vesicles from the plasma membrane.
Other compounds like Pitstop 2 and Chlorpromazine act by disrupting clathrin-mediated endocytosis, directly affecting the platform on which Eps15L1 operates. By inhibiting the assembly of clathrin-coated pits, these compounds prevent Eps15L1 from fulfilling its role in clathrin lattice formation and cargo selection. Ikarugamycin's inhibition of clathrin-independent endocytosis also demonstrates the specificity of these inhibitors, as they target distinct pathways essential for Eps15L1's endocytic trafficking activities. Furthermore, Genistein and Tyrphostin AG 1478 modulate the phosphorylation-dependent signaling pathways, thereby indirectly inhibiting Eps15L1 functions related to signal transduction and receptor internalization.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is an inhibitor of phosphoinositide 3-kinases (PI3K). Eps15L1, involved in endocytosis and signaling pathways, requires PI3K activity for membrane trafficking functions. Inhibition of PI3K by Wortmannin can therefore impede Eps15L1-mediated endocytosis and downstream signaling processes. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a GTPase inhibitor that targets dynamin, an essential molecule for clathrin-mediated endocytosis, a process where Eps15L1 is actively involved. By inhibiting dynamin, Dynasore disrupts endocytosis, thereby indirectly inhibiting Eps15L1 function related to vesicle formation and trafficking. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is a clathrin terminal domain inhibitor, directly interfering with clathrin-mediated endocytosis. Eps15L1, as a component of the endocytic machinery, requires functional clathrin interactions; the inhibition of clathrin by Pitstop 2 leads to a decrease in Eps15L1's role in endocytosis. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine is known to disrupt clathrin-mediated endocytosis by preventing the assembly of clathrin-coated pits. Given Eps15L1's involvement in the recruitment and assembly of endocytic components, its function is indirectly lessened by chlorpromazine's action on clathrin. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can impede cell signaling pathways involving phosphorylation. Since Eps15L1 is phosphorylated and involved in signaling cascades, genistein's inhibition of tyrosine kinases can result in reduced Eps15L1-mediated signal transduction. | ||||||
Tyrphostin AG 1478 | 175178-82-2 | sc-200613 sc-200613A | 5 mg 25 mg | $96.00 $421.00 | 16 | |
Tyrphostin AG 1478 is a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. Eps15L1 is known to associate with EGFR during endocytosis; thus, inhibition of EGFR by this compound can diminish the functional activity of Eps15L1 in receptor internalization and downstream signaling. | ||||||
Dansylcadaverine | 10121-91-2 | sc-214851 sc-214851A sc-214851B | 100 mg 250 mg 1 g | $52.00 $89.00 $240.00 | 4 | |
Monodansylcadaverine is a known inhibitor of transglutaminase and is also suggested to inhibit clathrin-mediated endocytosis. Eps15L1, being a part of the endocytic apparatus, is influenced by this inhibition, thus hindering its role in vesicle trafficking. | ||||||
Ikarugamycin | 36531-78-9 | sc-202179 | 500 µg | $189.00 | 4 | |
Ikarugamycin inhibits clathrin-independent endocytosis, affecting pathways where Eps15L1 is involved in non-clathrin-mediated vesicle formation. The inhibition of this endocytic route can constrain Eps15L1's function in these alternative endocytic pathways. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of the vacuolar type H+-ATPase (V-ATPase). By inhibiting V-ATPase, bafilomycin A1 affects endosomal acidification, which is crucial for the recycling and trafficking of endocytic vesicles, processes in which Eps15L1 is involved. | ||||||
D-Glucosamine | 3416-24-8 | sc-278917A sc-278917 | 1 g 10 g | $201.00 $779.00 | ||
Glucosamine is implicated in interfering with glycosylation processes. Since Eps15L1 is a glycoprotein, the inhibition of glycosylation can affect its stability and function, leading to decreased efficacy in its role in endocytic trafficking. | ||||||