EphB6 Activators
EphB6 activators encompass a diverse array of chemical compounds that indirectly influence the cellular pathways associated with EphB6. These chemicals do not activate EphB6 directly but modulate various signaling pathways that intersect with or influence EphB6 activity. The primary mechanism by which these compounds exert their influence is through the modulation of key signaling pathways like MAPK, PI3K/Akt, JNK, and EGFR. For example, MEK inhibitors like U0126 and PD98059, while primarily targeting the MAPK pathway, can create a cascade of cellular responses that ultimately affect EphB6-related signaling. This is significant in the context of cellular processes like differentiation, proliferation, and apoptosis, where EphB6 plays a role.
Similarly, compounds such as LY294002 and Wortmannin, which target the PI3K/Akt pathway, indirectly influence EphB6 activity by modulating cell survival and migration processes. The intersection of these pathways with EphB6 signaling denotes a complex network where changes in one pathway can have ripple effects on others. Other compounds like Forskolin and A23187 demonstrate how alterations in cellular components like cAMP levels or calcium ion concentration can influence EphB6-related pathways.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin acts as a JNK pathway activator. JNK signaling can intersect with EphB6 pathways, influencing cellular responses to stress and apoptosis. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP can modulate G protein-coupled receptor signaling, potentially affecting EphB6 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK, which is part of the MAPK pathway. Alterations in MAPK signaling can indirectly affect EphB6-related pathways, particularly in cell differentiation and proliferation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. By modulating PI3K/Akt pathway, it can influence EphB6 signaling indirectly, especially in processes like cell survival and migration. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, a p38 MAPK inhibitor, can impact the MAPK pathway. This pathway's modulation might influence EphB6 signaling in cellular stress responses and inflammation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is another MEK inhibitor affecting the MAPK pathway. This can lead to altered cellular responses in pathways where EphB6 is a component. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, impacting the JNK pathway. This alteration might affect EphB6-related signaling in cell stress and apoptotic processes. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore, which can elevate intracellular calcium levels. This elevation can influence EphB6 signaling pathways, particularly in cell adhesion and migration. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine, a kinase inhibitor, can affect multiple signaling pathways, potentially impacting EphB6 signaling in various cellular processes like apoptosis and differentiation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor, affecting the PI3K/Akt pathway. This can indirectly influence EphB6 activity, particularly in cell survival and migration. | ||||||