EphB Activators
EphB receptors constitute a unique subset of the Eph receptor family, which are pivotal in the intricate communication system of cellular signaling. These proteins are essential to the orchestration of cell positioning and tissue architecture, particularly within the nervous system, where they guide neuronal connections and synaptic plasticity. Beyond neural development, EphB receptors are also involved in vascular patterning, contributing to the formation and maintenance of the blood vessel network. The complex biological roles of EphB receptors are reflected in their intricate regulation and expression patterns, which can be influenced by a myriad of molecular cues and environmental factors. The modulation of EphB expression is a finely tuned process, often governed by the cellular context and signaling milieu.
Within the cellular microenvironment, various chemical compounds have been identified that can potentially serve as activators for the expression of EphB receptors. These activators work through diverse biochemical pathways, leveraging the cell's own regulatory mechanisms to induce the expression of these proteins. For example, certain small molecules can act on the genomic level, altering the chromatin landscape to facilitate transcription factor binding and gene transcription. Others interact with intracellular signaling cascades, leading to the activation of specific transcription factors that target the EphB gene promoters. Some activators may exert their effects indirectly, by inhibiting negative regulators of EphB expression, thereby lifting repressive influences on these genes. The molecular dance orchestrated by these activators is complex, involving precise temporal and spatial control to ensure that the upregulation of EphB fits the developmental and physiological context of the cell. The study of these chemical activators provides a rich understanding of the regulatory networks that govern cellular behavior and gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can trigger differentiation and development by binding to nuclear retinoic acid receptors, which directly initiate the transcription of developmental genes, possibly including those coding for EphB receptors. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin stimulates the enzyme adenylyl cyclase, increasing cAMP levels that in turn activate protein kinase A (PKA). PKA phosphorylates transcription factors like CREB, which may lead to the initiation of transcription of genes including those for EphB receptors. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine reduces DNA methylation, which can lead to the reactivation of genes that were epigenetically silenced, potentially including EphB receptor-encoding genes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a potent inhibitor of histone deacetylases, leading to hyperacetylation of histones, unwinding the chromatin structure, and facilitating the access of transcription machinery to genes that may encompass those encoding for EphB. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
The hormonally active form of Cholecalciferol, calcitriol, binds to the vitamin D receptor (VDR), a transcription factor that can stimulate the transcription of a wide variety of genes, potentially including those for EphB receptors. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
As a synthetic glucocorticoid, Dexamethasone binds to the glucocorticoid receptor, which may induce the expression of genes involved in anti-inflammatory responses and could include the upregulation of EphB receptors as part of a broader cellular response. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride can inhibit glycogen synthase kinase 3 (GSK-3), leading to the stabilization and accumulation of β-catenin, a transcriptional co-activator that may stimulate the transcription of genes including EphB receptor genes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate's inhibition of histone deacetylase leads to an open chromatin conformation and can stimulate transcription of genes by allowing transcription factors better access to DNA, which could include genes coding for EphB receptors. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
This compound selectively inhibits MEK1/2, enzymes in the MAPK/ERK pathway. This inhibition can lead to a decrease in the phosphorylation of downstream targets, resulting in an altered transcriptional program that may upregulate genes including EphB. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 specifically inhibits p38 MAPK, altering the signaling cascade that usually responds to stress stimuli. This can lead to changes in the expression of genes responsible for cell cycle regulation, potentially upregulating EphB receptor gene expression. | ||||||