ENT1 Activators
ENT1 activators are a class of chemical compounds that specifically target and interact with the equilibrative nucleoside transporter 1 (ENT1), a membrane protein responsible for the transport of nucleosides, including adenosine and uridine, across cell membranes. ENT1 is found in various tissues throughout the human body and plays a crucial role in regulating the intracellular levels of these nucleosides. Activation of ENT1 by specific ligands or activators can modulate its transport activity, influencing the concentration of nucleosides within cells. The primary function of ENT1 activators is to enhance the uptake of nucleosides into cells, which can have significant downstream effects on various cellular processes.
ENT1 activators are of particular interest in the field of molecular biology and cell physiology due to their ability to fine-tune nucleoside transport. This modulation of nucleoside uptake can impact several physiological processes, including cell proliferation, DNA repair, and neurotransmission. By altering the intracellular levels of nucleosides, ENT1 activators can indirectly influence these processes and may have implications in the context of research on cellular signaling and metabolism. Researchers are continually exploring the potential applications of ENT1 activators in a variety of cellular and biochemical studies to better understand the intricate regulatory mechanisms governed by nucleoside transporters like ENT1. ENT1 activators constitute a chemical class of compounds that interact with the equilibrative nucleoside transporter 1, affecting the transport of nucleosides across cell membranes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, can modulate gene expression, potentially increasing ENT1 expression via glucocorticoid receptor interaction. This response might be part of the body's mechanism to enhance nucleoside availability under stress conditions. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can lead to the upregulation of various proteins, including ENT1. This process might facilitate enhanced cellular uptake of nucleosides for various metabolic needs. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin plays a crucial role in glucose metabolism and may also influence ENT1 expression. The modulation of ENT1 could assist in balancing nucleoside uptake, especially in tissues sensitive to insulin signaling, such as muscle and adipose tissues. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, is involved in cell growth and differentiation. It might upregulate ENT1 expression to meet the increased demand for nucleosides during these processes, ensuring adequate nucleotide supply for DNA synthesis. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol, an estrogen hormone, may regulate ENT1 expression as part of its wide-ranging effects on cell growth and metabolism. Enhanced ENT1 expression could support increased nucleoside uptake for DNA synthesis in estrogen-responsive tissues. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium impacts various cellular processes, and its influence on ENT1 expression could be linked to its role in mood stabilization. By modulating ENT1, lithium might affect nucleoside availability and balance, potentially influencing neurotransmitter synthesis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound from turmeric, has anti-inflammatory and antioxidant properties. It might upregulate ENT1 expression as part of its protective effects against oxidative stress, ensuring adequate nucleoside transport under challenging conditions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, found in grapes and berries, has antioxidant and anti-inflammatory properties. Its potential to increase ENT1 expression might be related to its role in promoting cellular resilience against oxidative stress, ensuring stable nucleoside transport. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine stimulates the central nervous system and might also influence ENT1 expression. By modulating ENT1, caffeine could potentially affect nucleoside transport and availability, potentially influencing energy metabolism and neurotransmitter synthesis. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide is a reactive oxygen species that can cause oxidative stress. Cells might upregulate ENT1 in response to oxidative stress as a protective mechanism, ensuring stable nucleoside transport and contributing to cellular resilience. | ||||||