EndoV Activators
Endonuclease V, often abbreviated as EndoV, is a vital enzyme found across multiple life forms, from bacteria to mammals. It plays a significant role in DNA repair, particularly in the identification and excision of deaminated bases, which are a common form of DNA damage. The enzyme's main function is to recognize and remove inosine, a deaminated derivative of adenosine, from DNA, preventing mutagenesis and maintaining genomic stability.EndoV is unique among DNA repair enzymes due to its distinctive mechanism of action. It cleaves the second phosphodiester bond 3' to the damaged site, leaving a nick with 3'-hydroxyl and 5'-phosphate termini. This action differentiates it from most other DNA glycosylases, which typically cleave the glycosidic bond of the damaged base.
In humans, the EndoV enzyme is encoded by the ENDOV gene, and its malfunction can lead to genomic instability and contributes to pathogenesis, including cancer. Recent studies have also indicated a possible role of EndoV in processing RNA, expanding its functional significance beyond DNA repair.EndoV's unique functionality and broad presence across species make it an attractive target for biochemical research and development. Its involvement in the maintenance of genomic integrity could have implications for various diseases including canacer. Understanding the exact mechanism and regulation of EndoV may provide new insights into the intricate network of DNA repair and its relationship with human disease.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
A chemotherapy drug that induces DNA damage, potentially increasing the demand for DNA repair enzymes like EndoV. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $110.00 $386.00 | 8 | |
Similar to Cisplatin, it causes DNA damage, potentially enhancing the activity of DNA repair mechanisms involving EndoV. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
An anthracycline that intercalates into DNA, inducing damage and potentially upregulating DNA repair pathways including those involving EndoV. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Causes DNA damage by inhibiting topoisomerase II, potentially influencing EndoV activity indirectly through increased DNA repair requirements. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Generates DNA crosslinks, potentially enhancing the activity of DNA repair enzymes like EndoV. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Induces DNA strand breaks, potentially increasing the need for DNA repair enzymes such as EndoV. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
An inhibitor of topoisomerase I, leading to DNA damage and potentially influencing EndoV activity. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $55.00 $130.00 | 2 | |
An alkylating agent causing DNA damage, potentially enhancing the activity of DNA repair pathways involving EndoV. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Inhibits ribonucleotide reductase, leading to DNA replication stress and potentially increasing the role of DNA repair enzymes like EndoV. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
An inhibitor of DNA polymerases, inducing replication stress and potentially influencing DNA repair pathways involving EndoV. | ||||||