Ena1 Activators
Ena1 activators are chemical compounds that indirectly modulate the activity of the Ena1 protein, a type of sodium/potassium-transporting ATPase found in yeast. These activators do not directly bind to or alter the function of Ena1. Instead, they influence various cellular signaling pathways that can lead to changes in Ena1 activity. These compounds operate within intricate cellular signaling networks and can affect multiple targets. For instance, compounds like anisomycin engage with the MAPK pathways, which are involved in cellular responses to stress, potentially leading to modifications in the expression or function of Ena1. Similarly, agents like lithium chloride affect glycogen synthase kinase activity, which could alter cellular ion balance and thereby indirectly impact Ena1 function.
Within the biochemical landscape of the cell, compounds like Forskolin and phorbol esters exert their effects by modulating the levels of second messengers such as cAMP and activating protein kinases, respectively. This can lead to phosphorylation events that might regulate Ena1's activity. Others, like calyculin A and okadaic acid, inhibit phosphatases, thus affecting the phosphorylation status of a broad spectrum of proteins, potentially including those that control ion transport mechanisms.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a pyrrolidine antibiotic which acts as a protein synthesis inhibitor and activates MAPK pathways like p38. This, in turn, can influence the cellular stress response mechanisms that might impact the activity of proteins such as ENa1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 is a well-known p38 MAPK inhibitor. While typically an inhibitor, it can have complex effects on cellular signaling that might indirectly affect other pathways compensatorily, potentially affecting ENa1 activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to influence several signaling pathways, including GSK-3 inhibition. GSK-3 modulates various cellular processes that could have downstream effects on ion transport and homeostasis. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $46.00 $249.00 | 2 | |
DOG is a synthetic diacylglycerol analog. Diacylglycerol (DAG) is an activator of protein kinase C (PKC), which can regulate various ion channels and pumps by phosphorylation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing intracellular cAMP levels, which activates PKA and can modulate ion transport mechanisms. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a PKC activator, which through PKC signaling can alter the function of various ion transporters and channels, potentially affecting ENa1. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 and 2A, which would prevent dephosphorylation of proteins, potentially keeping proteins such as ENa1 in an active state. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Similar to Calyculin A, Okadaic Acid inhibits protein phosphatases, thus can indirectly influence phosphorylation states of membrane pumps and transporters. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG has been shown to have various effects on cell signaling pathways, including modulation of MAPKs, which could indirectly influence ion transport. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
This compound is an inhibitor of MEK, which acts upstream of ERK in the MAPK pathway. It could have indirect effects on other MAPK pathways or compensatory cellular responses. | ||||||