ELP3 Activators
ELP3 activators are a class of chemicals that can indirectly enhance the activity of ELP3, a component of the Elongator complex involved in histone acetylation. The majority of these activators function by inhibiting HDACs or HATs, which are key enzymes in the regulation of histone acetylation and deacetylation, a critical process in the control of gene expression. Inhibition of these enzymes promotes histone acetylation, leading to a more open chromatin state and increased gene transcription. As ELP3 is involved in histone acetylation, these HDAC or HAT inhibitors can indirectly enhance ELP3 activity.
The activator chemicals include HDAC inhibitors such as sodium butyrate, trichostatin A, nicotinamide, curcumin, vorinostat, belinostat, SAHA, tubastatin A, and PCI-34051. Thesecompounds act by inhibiting HDACs to promote histone acetylation, thus indirectly enhancing ELP3 activity. On the other hand, HAT inhibitors such as anacardic acid, garcinol, and C646 work by inhibiting HATs, which can also indirectly activate ELP3. The inhibition of HATs disrupts the balance of histone acetylation and deacetylation, which can indirectly activate ELP3, as ELP3 is part of the Elongator complex involved in histone acetylation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that acts as a histone deacetylase (HDAC) inhibitor. By inhibiting HDAC, it promotes histone acetylation. ELP3 functions as part of the Elongator complex which is implicated in histone acetylation, hence sodium butyrate can indirectly upregulate ELP3 activity. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide is an inhibitor of sirtuins, a family of HDACs. Inhibition of sirtuins promotes acetylation, indirectly enhancing ELP3 activity due to ELP3's involvement in the acetylation process. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit HDACs and promote histone acetylation, which indirectly enhances ELP3 activity due to ELP3's role in the Elongator complex implicated in histone acetylation. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat is an HDAC inhibitor that enhances histone acetylation, indirectly enhancing ELP3 activity due to its role in the Elongator complex implicated in histone acetylation. | ||||||
Tubastatin A | 1252003-15-8 | sc-507298 | 10 mg | $114.00 | ||
Tubastatin A is a HDAC6 inhibitor. By inhibiting HDAC6, it enhances histone acetylation, indirectly activating ELP3 due to its role in the Elongator complex implicated in histone acetylation. | ||||||
PCI-34051 | 950762-95-5 | sc-364566 sc-364566A | 10 mg 100 mg | $189.00 $1671.00 | 5 | |
PCI-34051 is a HDAC8 inhibitor. By inhibiting HDAC8, it enhances histone acetylation, indirectly enhancing ELP3 activity due to its role in the Elongator complex implicated in histone acetylation. | ||||||