eIF3K Activators
The eIF3K activators represent a distinctive class of chemical compounds that exert their influence on the eukaryotic translation initiation factor 3 (eIF3K). This class of molecules specifically targets eIF3K, a crucial component of the eIF3 complex, which plays a central role in the initiation phase of protein synthesis. The eIF3 complex is composed of multiple subunits, each contributing to the intricate regulation of translation initiation. Among these subunits, eIF3K stands out as a key regulatory element that governs the assembly and stability of the entire complex. Activators of eIF3K are designed to modulate the activity of this kinase, thereby influencing the overall translation initiation process.
The mechanism underlying eIF3K activation involves intricate interactions with its substrate and subsequent signaling cascades that regulate translation initiation. These activators are designed to fine-tune the phosphorylation state of eIF3K, thereby impacting its downstream targets within the translation initiation machinery. The modulation of eIF3K activity can lead to nuanced adjustments in protein synthesis rates, allowing for a more precise control of cellular responses to various stimuli.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that could enable eIF3K activation indirectly by controlling mTOR-mediated protein synthesis initiation | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $131.00 $651.00 | 7 | |
An mTOR inhibitor that might enable eIF3K activation indirectly by controlling mTOR-dependent protein synthesis | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor that can enable eIF3K activation indirectly by modulating the PI3K/AKT/mTOR pathway, a key element in protein synthesis | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that might enable eIF3K activation indirectly by modulating the PI3K/AKT/mTOR pathway, a major controller of protein synthesis | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $188.00 $327.00 | 1 | |
An AKT inhibitor that could enable eIF3K activation indirectly by controlling the PI3K/AKT/mTOR pathway, necessary for protein synthesis | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
An AKT inhibitor that can enable eIF3K activation indirectly by modulating the PI3K/AKT/mTOR pathway, essential for protein synthesis | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MAPK inhibitor that could enable eIF3K activation indirectly by controlling the MAPK pathway, a key component in protein synthesis | ||||||
SCH772984 | 942183-80-4 | sc-473205 | 5 mg | $370.00 | 5 | |
An ERK inhibitor that can enable eIF3K activation indirectly by modulating the MAPK/ERK pathway, important for protein synthesis | ||||||
ERK Inhibitor II, FR180204 | 865362-74-9 | sc-203945 sc-203945A sc-203945B sc-203945C | 1 mg 5 mg 10 mg 50 mg | $110.00 $165.00 $239.00 $942.00 | 45 | |
An ERK inhibitor that might enable eIF3K activation indirectly by controlling the MAPK/ERK pathway, crucial for protein synthesis | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
A hormone that activates the PI3K/AKT/mTOR pathway, potentially enabling eIF3K activation indirectly by promoting protein synthesis | ||||||