eIF3δ Activators
eIF3δ is a subunit of the eukaryotic initiation factor 3 (eIF3) complex, which is pivotal in the initiation phase of mRNA translation. The eIF3 complex is the largest of the eIFs and is responsible for several key functions during the initiation of protein synthesis. It helps in the recruitment of the 40S ribosomal subunit to the 5' end of mRNA, aids in the scanning of mRNA for the start codon, and assists in the joining of the 60S ribosomal subunit to form the 80S initiation complex, thereby facilitating the start of polypeptide synthesis.
The δ subunit, specifically, is one of the multiple non-core subunits of the eIF3 complex, and while its exact role is not as well-characterized as some of the other subunits, it is believed to contribute to the structural stability and function of the eIF3 complex. The expression and activity of eIF3δ are crucial for the overall process of translation initiation, and thus for the regulation of protein synthesis, which is fundamental to cell growth, cycle progression, and response to cellular stress and nutrients.Alterations in the expression or function of eIF3δ can have significant implications for cellular homeostasis and have been associated with various diseases, including cancer. The eIF3 complex, including eIF3δ, is subject to regulation by various signaling pathways that respond to intracellular and extracellular cues, ensuring that protein synthesis is tightly controlled in accordance with the needs and conditions of the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
It increases cAMP levels, which can activate PKA and potentially enhance eIF3δ expression through cAMP response element-binding protein (CREB). | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This green tea polyphenol may modulate signaling pathways that control protein synthesis and eIF3δ expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
By inhibiting GSK-3, lithium chloride may affect signaling pathways that regulate translation initiation factors like eIF3δ. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A vitamin A derivative that influences gene expression and might upregulate eIF3δ as part of cellular differentiation processes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, it can alter chromatin and gene expression, potentially increasing eIF3δ levels. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Another HDAC inhibitor that can change gene expression profiles, possibly including that of eIF3δ. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cAMP analog that may upregulate genes with cAMP-responsive elements, potentially including eIF3δ. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
By affecting DNA synthesis and repair, methotrexate could influence the expression of various genes, including eIF3δ. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
This chemotherapy agent can cause DNA damage, potentially altering the expression of genes involved in the stress response, including eIF3δ. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
As a SERM, tamoxifen can alter the transcription of estrogen-responsive genes, which may include eIF3δ. | ||||||