EGFL4 Activators
EGFL4 can initiate a range of intracellular signaling pathways that lead to its activation. Phorbol 12-myristate 13-acetate (PMA) is one such activator, which can directly activate protein kinase C (PKC). This kinase plays a pivotal role in cell signaling and can phosphorylate EGFL4, changing its conformation and thereby increasing its activity. Similarly, ionomycin acts as a calcium ionophore, raising intracellular calcium levels, which in turn can activate calcium-dependent protein kinases. These kinases can lead to the phosphorylation and activation of EGFL4. Forskolin, by increasing cyclic AMP (cAMP) levels through the activation of adenylyl cyclase, indirectly activates protein kinase A (PKA), which can also target proteins in the EGFL4 pathway, leading to activation.
Epidermal growth factor (EGF) to its receptor triggers a cascade involving the MAPK/ERK pathway, which can lead to EGFL4 activation. Insulin engages its receptor and initiates a series of phosphorylation events via the PI3K/Akt pathway. The activation of this pathway can influence the activation state of EGFL4. Vascular endothelial growth factor (VEGF) interacts with its receptors to activate PLCγ and PI3K pathways, both of which are capable of influencing the phosphorylation status of EGFL4. Isoproterenol, acting as a beta-adrenergic agonist, increases cAMP levels and consequently activates PKA, which is capable of phosphorylating and activating EGFL4. Histamine, by binding to its receptors, activates phospholipase C (PLC), resulting in increased intracellular calcium and PKC activation, which in turn can lead to EGFL4 activation. Thrombin, through its protease activity, can initiate G-protein coupled receptor signaling, leading to the activation of EGFL4 by downstream kinases. Lastly, hydrogen peroxide and lysophosphatidic acid (LPA), through oxidative stress signaling and G-protein coupled receptor activation respectively, modulate kinase activity, which can result in the phosphorylation and activation of EGFL4. Anandamide, by activating cannabinoid receptors, influences cAMP/PKA and PLC/PKC pathways, which can phosphorylate and activate EGFL4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA directly activates protein kinase C (PKC), which is involved in signaling cascades that can lead to the activation of EGFL4 through phosphorylation, changing its conformation and increasing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration, which can activate calcium-dependent protein kinases, potentially leading to the activation of the EGFL4 protein through subsequent phosphorylation events. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can activate the insulin receptor, initiating a cascade of phosphorylation events through the PI3K/Akt pathway, which might have downstream effects leading to the activation of EGFL4, as EGFL4 could be influenced by PI3K/Akt-mediated processes. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, which activates PKA, and PKA can potentially lead to the activation of EGFL4 through phosphorylation of proteins in its signaling pathway. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine binds to its receptors, leading to activation of PLC, which can result in increased intracellular calcium and activation of PKC. PKC can phosphorylate proteins in the EGFL4 pathway, leading to activation of EGFL4. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Thrombin is a serine protease that can activate PAR receptors leading to G-protein coupled receptor signaling, which might result in the activation of EGFL4 through downstream kinases that phosphorylate and activate EGFL4. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide is involved in oxidative stress signaling and can act as a secondary messenger that might lead to the activation of EGFL4 by modulating the activity of kinases that phosphorylate and activate EGFL4. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
LPA activates G-protein coupled receptors, leading to activation of PLC, which increases calcium levels and activates PKC. PKC can then phosphorylate proteins in the EGFL4 pathway, potentially leading to the activation of EGFL4. | ||||||