EG668114 Activators
Lipo2 Activators are a class of biochemical compounds that interact with the lipase, member O2, an enzyme associated with lipid metabolism. These activators encompass a broad spectrum of molecules that initiate a cascade of intracellular events leading to the modulation of lipase activity. The primary mechanism of action for many of these activators involves the regulation of cyclic adenosine monophosphate (cAMP) levels within cells. For instance, compounds like isoproterenol and forskolin directly stimulate the production of cAMP by activating adenylyl cyclase, either via adrenergic receptor engagement or direct enzyme activation, respectively. On the other hand, substances such as IBMX and caffeine elevate cAMP levels by inhibiting phosphodiesterases, enzymes responsible for the degradation of cAMP. The increase in intracellular cAMP is a pivotal step, as it activates protein kinase A (PKA), a kinase that can phosphorylate a variety of substrates, including proteins involved in lipid mobilization processes.
Other Lipo2 Activators function by modulating nuclear receptor pathways. These activators include molecules that engage peroxisome proliferator-activated receptors (PPARs), such as GW 7647 and L-165,041, which are selective agonists for PPAR-alpha and PPAR-delta, respectively. The binding of these activators to their receptors leads to altered transcriptional activities, resulting in the upregulation of genes involved in lipid metabolism. Additionally, activators like oleoylethanolamide exert their effects through similar receptors, influencing the expression of enzymes that contribute to lipolysis. SRT1720, a different type of activator, enhances the activity of lipase, member O2 by activating sirtuin 1 (SIRT1), a protein involved in the deacetylation of various metabolic enzymes and transcription factors, thereby affecting lipid metabolism at the post-translational level. Moreover, some compounds indirectly influence lipase activity by participating in feedback mechanisms or compensatory pathways that maintain lipid homeostasis. For instance, cholestyramine binds bile acids in the gastrointestinal tract, which indirectly necessitates an increase in lipolytic activity to provide substrates for hepatic bile acid synthesis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases intracellular cAMP levels by activating adrenergic receptors. Elevated cAMP activates PKA, which can phosphorylate downstream targets, thereby enhancing the activity of lipase, member O2 by promoting its association with lipid substrates. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX acts as a non-selective inhibitor of phosphodiesterases, thereby preventing the breakdown of cAMP. This results in elevated levels of cAMP within the cell, which indirectly enhances the activity of lipase, member O2 through PKA activation. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Nicotinic acid can activate G protein-coupled receptors that inhibit adenylate cyclase activity, leading to reduced cAMP levels. This may result in compensatory mechanisms that enhance lipase, member O2 activity to maintain energy homeostasis. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $90.00 $194.00 | 1 | |
Oleoylethanolamide is a lipid signaling molecule that activates PPAR-alpha, a nuclear receptor that regulates lipid metabolism. Activation of PPAR-alpha can lead to an increase in the expression of genes involved in lipolysis, indirectly enhancing the activity of lipase, member O2. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine is a competitive inhibitor of phosphodiesterases, leading to an increase in cAMP levels. Elevated cAMP activates PKA, which in turn can enhance the activity of lipase, member O2 by phosphorylating regulatory sites on the enzyme or its cofactors. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), which can increase fatty acid oxidation and lipolysis. AMPK activation can enhance the activity of lipase, member O2 by phosphorylating key targets involved in the lipolytic process. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $49.00 $170.00 $267.00 $661.00 | 6 | |
GW 7647 is a potent PPAR-alpha agonist that modulates the expression of genes involved in lipid metabolism. By activating PPAR-alpha, GW 7647 can indirectly enhance the activity of lipase, member O2 by increasing the expression of lipolytic enzymes. | ||||||
L-165041 | 79558-09-1 | sc-203094 | 5 mg | $156.00 | ||
L-165,041 is a PPAR-delta agonist that regulates genes involved in lipid metabolism. Activation of PPAR-delta can enhance the activity of lipase, member O2 by upregulating the expression of proteins that facilitate lipolysis. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
SRT1720 is an activator of SIRT1, which is involved in the regulation of lipid metabolism through deacetylation of transcription factors and enzymes. Activation of SIRT1 can enhance lipase, member O2 activity by modulating its interaction with lipid substrates. | ||||||
CHOLESTYRAMINE RESIN | 11041-12-6 | sc-507509 | 5 g | $210.00 | ||
Cholestyramine binds bile acids in the intestine, leading to upregulation of hepatic bile acid synthesis from cholesterol. This process demands increased lipolysis, indirectly enhancing the activity of lipase, member O2 to supply the necessary fatty acids. | ||||||