Date published: 2025-11-25

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EG666203 Inhibitors

EG666203 inhibitors are a class of chemical compounds characterized by their ability to specifically inhibit the activity of a particular biological target, associated with cellular pathways involved in signal transduction, protein-protein interactions, and metabolic processes. These inhibitors often share a core structure that allows them to bind to their intended target with high specificity and affinity. The binding typically induces a conformational change in the target protein, altering its function or impeding its activity. The molecular architecture of EG666203 inhibitors often includes functional groups that interact with the target's active site or allosteric site, stabilizing the complex and preventing the normal activity of the protein. As a result, these inhibitors can regulate various cellular processes and pathways, offering potential tools for modulating specific biochemical activities in research settings.

Chemically, EG666203 inhibitors display a range of structural variations that contribute to their binding properties and biological effects. These compounds may have features such as aromatic rings, heterocycles, and side chains containing polar or non-polar groups to enhance solubility, permeability, and binding capabilities. Structural optimization is often carried out to fine-tune their selectivity, ensuring that they interact primarily with their intended targets while minimizing off-target effects. The versatility of these inhibitors makes them useful for dissecting signaling pathways and understanding the function of the biological targets they inhibit. In biochemical studies, EG666203 inhibitors serve as valuable tools for probing the activity and regulation of proteins, providing insights into the fundamental mechanisms of cellular functions. Their design and synthesis require a detailed understanding of both the target's structure and the desired inhibitory mechanism, resulting in a class of compounds that are diverse, potent, and tailored for specific biochemical interactions.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

Inhibits histone deacetylases, leading to increased acetylation of histones, which can enhance the transcription of genes, potentially including those encoding Pramel50.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

Induces DNA demethylation, which can activate the transcription of silenced genes, potentially increasing Pramel50 expression if it is epigenetically regulated.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

Inhibits the ubiquitin-proteasome pathway, leading to reduced degradation of ubiquitinated proteins, which may stabilize Pramel50 if it is prone to proteasomal degradation.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$40.00
$82.00
$256.00
127
(5)

Blocks eukaryotic ribosomal translocation, inhibiting protein synthesis, which would decrease the synthesis of most proteins, including Pramel50.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

A broad-spectrum kinase inhibitor, which can inhibit protein kinases that phosphorylate Pramel50, affecting its activity and/or stability.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$94.00
$349.00
114
(2)

Inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), disrupting calcium homeostasis, which may influence calcium-dependent regulation of Pramel50.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Specifically inhibits the 26S proteasome, potentially leading to increased levels of Pramel50 by reducing its degradation if it is regulated by ubiquitination.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

Inhibits phosphoinositide 3-kinases (PI3K), which could reduce AKT signaling, affecting downstream proteins including Pramel50 if it is downstream of this pathway.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

Inhibits mitogen-activated protein kinase kinase (MEK), which could affect ERK signaling and potentially alter the phosphorylation state of Pramel50 if it is a substrate.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Binds to FK506-binding protein (FKBP12) and inhibits mammalian target of rapamycin (mTOR), which may affect Pramel50 if it is involved in pathways regulated by mTOR.