EG665956 Activators
Defensin, alpha, 43 activators encompass a range of compounds that indirectly enhance the antimicrobial activity of DEFA43 by influencing the immune system's regulatory mechanisms and the expression of this peptide. Zinc gluconate, by reinforcing epithelial barriers, ensures that DEFA43 is effectively concentrated at microbial entry points, thus enhancing its protective role. Vitamin D3 and retinoic acid, both crucial for immune function modulation, are known to upregulate the expression of DEFA43, thus increasing its availability and activity against pathogens. Butyrate and lactoferrin, through their action on the gut mucosa and immune cells respectively, alsoelevate the levels of DEFA43, contributing to a fortified antimicrobial defense. Resveratrol, glycyrrhizin, curcumin, and epigallocatechin gallate (EGCG) exert their effects by modulating signaling pathways like NF-κB, which are integral to the immune response and directly linked to the induction of defensin expression, including DEFA43. The enhancement of DEFA43 function by these compounds is attributed to their capacity to upregulate the immune response at a molecular level, ensuring that DEFA43 is present in adequate amounts to exert its antimicrobial effects.
Micronutrients such as selenium play a foundational role in immune system health and, by extension, in the regulation of defensin levels including DEFA43. Omega-3 fatty acids, known for their broad immunomodulatory effects, have been shown to influence the expression of antimicrobial peptides, thus indirectly contributing to the heightened functional activity of DEFA43. Nitric oxide donors like sodium nitroprusside modulate various aspects of the immune response, including the activity of antimicrobial peptides, thereby supporting the enhanced presence and efficacy of DEFA43 in the immune system's arsenal against pathogens.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is crucial for maintaining mucosal membrane integrity and immune function. Zinc gluconate can enhance the activity of defensins by reinforcing epithelial barriers, which in turn can lead to higher concentration and effectiveness of DEFA43 at the site of microbial invasion. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 modulates the immune system and is known to induce the expression of defensins. By increasing the systemic levels of Vitamin D3, the expression of DEFA43 can be enhanced, leading to improved antimicrobial activity. | ||||||
Lactoferrin | 146897-68-9 | sc-394420 sc-394420A sc-394420B sc-394420C | 10 mg 50 mg 100 mg 1 g | $120.00 $400.00 $569.00 $1465.00 | ||
Lactoferrin boosts the immune response and has been reported to induce the expression of defensins. The presence of lactoferrin can thus enhance the functional activity of DEFA43 by increasing its expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, derived from Vitamin A, influences mucosal immunity and can induce the production of defensins. By promoting the release of DEFA43, retinoic acid can enhance its antimicrobial functions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol affects the NF-κB signaling pathway, which is involved in the immune response and the upregulation of defensins. By activating this pathway, resveratrol can enhance the functional activity of DEFA43. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has immunomodulatory effects and can induce the expression of defensins. By enhancing the immune response, curcumin can indirectly increase the functional activity of DEFA43. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, can modulate immune system functions and has been shown to upregulate the production of defensins. This action can enhance the activity of DEFA43. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
Selenium is an essential micronutrient that plays a key role in the immune system. Adequate selenium nutrition can enhance the activity of defensins by promoting overall immune health and the antimicrobial response. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $42.00 $83.00 $155.00 | 7 | |
Nitric oxide plays a role in the immune system and can enhance the activity of antimicrobial peptides. Donors like sodium nitroprusside can indirectly enhance the activity of DEFA43 by modulating immune responses. | ||||||