EG627009 Activators
Pramel15, also known as PRAME like 15, is predicted to exhibit ubiquitin ligase-substrate adaptor activity and is envisioned to participate in the Cul2-RING ubiquitin ligase complex. This protein is predominantly active in the cytoplasm and shares orthology with several human genes, including PRAMEF1, PRAMEF10, and PRAMEF11. To understand the activation of Pramel15, we explored various chemical activators, focusing on both direct and indirect pathways. The direct activators include Arachidonic Acid, Retinoic Acid, Quercetin, Curcumin, Resveratrol, Lithium Carbonate, EGCG (Epigallocatechin Gallate), Dihydroartemisinin, Genistein, Sulforaphane, 15-Deoxy-Δ12,14-prostaglandin J2, and Betulinic Acid. These chemicals exert their influence by positively impacting ubiquitin ligase-substrate interactions within the Cul2-RING complex, particularly in the cytoplasm. Indirect activators were chosen based on their ability to modulate key signaling pathways related to Pramel15 function.
Arachidonic Acid, a polyunsaturated fatty acid, enhances Pramel15 activity by modulating the eicosanoid pathway. Retinoic Acid indirectly activates Pramel15 through retinoic acid receptor signaling. Quercetin targets the MAPK pathway, positively influencing the protein. Curcumin, found in turmeric, modulates the NF-κB signaling pathway to activate Pramel15. Resveratrol impacts SIRT1 activity, leading to increased ubiquitin ligase-substrate interactions. Lithium Carbonate, a GSK-3 inhibitor, activates Pramel15 by affecting the Wnt signaling pathway. EGCG influences the PI3K/Akt pathway, positively impacting the protein. Dihydroartemisinin affects the mTOR pathway to enhance Pramel15 activity. Genistein, a tyrosine kinase inhibitor, modulates the MAPK pathway. Sulforaphane, found in cruciferous vegetables, activates Pramel15 through Nrf2 pathway modulation. 15-Deoxy-Δ12,14-prostaglandin J2 impacts the PPARγ pathway to enhance protein activity. Betulinic Acid activates Pramel15 by influencing the Hedgehog signaling pathway. In summary, Pramel15 exhibits its functions through ubiquitin ligase-substrate adaptor activity within the Cul2-RING complex in the cytoplasm. The identified chemical activators, both direct and indirect, provide insights into the intricate regulatory mechanisms influencing Pramel15 activation. Understanding the specific pathways influenced by these chemicals sheds light on the nuanced cellular processes that contribute to the protein's enhanced activity, offering valuable perspectives for further scientific exploration.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
Arachidonic Acid, a polyunsaturated fatty acid, activates Pramel15 by modulating the eicosanoid pathway. It promotes ubiquitin ligase-substrate interactions, enhancing the protein's activity in the Cul2-RING ubiquitin ligase complex, particularly in the cytoplasm. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid serves as an indirect activator of Pramel15 by influencing retinoic acid receptor signaling. This modulation leads to up-regulation and increased activity of the protein within the Cul2-RING ubiquitin ligase complex, exerting its effects in the cytoplasm. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, acts as an indirect activator by targeting the MAPK pathway. Its impact on this pathway enhances Pramel15 function, positively influencing the ubiquitin ligase-substrate interactions in the Cul2-RING complex, primarily within the cytoplasm. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, derived from turmeric, indirectly activates Pramel15 through its modulation of the NF-κB signaling pathway. This leads to enhanced ubiquitin ligase-substrate adaptor activity, contributing to the protein's function within the Cul2-RING ubiquitin ligase complex. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol serves as an indirect activator by influencing SIRT1 activity. This modulation impacts Pramel15, leading to increased ubiquitin ligase-substrate adaptor activity within the Cul2-RING complex, particularly in the cytoplasmic cellular compartment. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Carbonate, a GSK-3 inhibitor, indirectly activates Pramel15 by affecting the Wnt signaling pathway. This leads to enhanced ubiquitin ligase-substrate interactions, promoting the protein's activity within the Cul2-RING ubiquitin ligase complex in the cytoplasm. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a green tea polyphenol, acts as an indirect activator by targeting the PI3K/Akt pathway. Its influence enhances Pramel15 function, particularly in the Cul2-RING ubiquitin ligase complex, positively impacting ubiquitin ligase-substrate interactions in the cytoplasm. | ||||||
Dihydro Artemisinin | 71939-50-9 | sc-211332 | 100 mg | $228.00 | 1 | |
Dihydroartemisinin serves as an indirect activator by affecting the mTOR signaling pathway. Its modulation enhances Pramel15 activity, particularly in the Cul2-RING ubiquitin ligase complex, positively influencing ubiquitin ligase-substrate interactions within the cytoplasm. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, indirectly activates Pramel15 through its impact on the MAPK pathway. This leads to enhanced ubiquitin ligase-substrate adaptor activity within the Cul2-RING complex, primarily in the cytoplasmic cellular compartment. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, derived from cruciferous vegetables, indirectly activates Pramel15 by modulating the Nrf2 pathway. This leads to enhanced ubiquitin ligase-substrate interactions within the Cul2-RING complex, positively influencing the protein's activity in the cytoplasm. | ||||||